Recombinant Human CTF1, StrepII-tagged

• Cat.No.: CTF1-251H
• Product Overview: Purified, full-length human recombinant CTF1 or Cardiotrophin 1protein (amino acids 1-201, 201 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 21.1 kDa. (Accession NP_001321.1; UniProt Q16619)

Specification

• Description: CTF1 is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor.
• Source: Human Cells
• Species: Human
• Tag: StrepII
• Form: Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free).
• Protein length: 1-201, 201 a.a.
• AA Sequence: SRREGSLEDPQTDSSVSLLPHLEAK IRQTHSLAHLLTKYAEQLLQEYVQL QGDPFGLPSFSPPRLPVAGLSAPAP SHAGLPVHERLRLDAAALAALPPL LDAVCRRQAELNPRAPRLLRRLEDA ARQARALGAAVEALLAALGAANRGP RAEPPAATASAASATGVFPAKVLGL RVCGLYREWLSRTEGDLGQLLPGGS A
• Endotoxin: <0.1 eu per ug protein by lal
• Purity: ~80% pure by SDS-PAGE
• Storage: 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles.
• Reconstitution: Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml.

Gene Information

• Gene Name: CTF1 cardiotrophin 1 [ Homo sapiens ]
• Official Symbol: CTF1
• Synonyms: CTF1; cardiotrophin 1; cardiotrophin-1; CT 1; CT1; cardiophin 1; CT-1
• Gene ID: 1489
• mRNA Refseq: NM_001142544
• Protein Refseq: NP_001136016
• MIM: 600435
• UniProt ID: Q16619
• Chromosome Location: 16p11.2
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem
• Function: cytokine activity; leukemia inhibitory factor receptor binding

Reviews

08/19/2022

Swift protein characterization services; key for our research projects.

09/28/2019

Expertise in protein engineering; invaluable for our lab's needs.

08/31/2019

High-quality protein-protein interaction assays; essential for our experiments.

Q&As

How does CTF1 contribute to metabolic regulation, particularly in obesity and diabetes?

CTF1 plays a role in metabolic regulation, impacting processes related to obesity and diabetes.

What are the effects of CTF1 on neuronal survival and regeneration in neurodegenerative diseases?

CTF1 supports neuronal survival and regeneration, offering potential benefits in neurodegenerative conditions.

How does CTF1 influence cardiac hypertrophy and heart failure progression?

CTF1 promotes cardiac hypertrophy and can contribute to heart failure progression by influencing heart muscle cell growth.

How do alterations in CTF1 expression affect tissue repair and regeneration after injury?

Changes in CTF1 expression are important for tissue repair and regeneration, particularly following injury.

What role does CTF1 play in the regulation of muscle regeneration and muscle wasting diseases?

CTF1 aids in muscle regeneration and can be involved in the pathology of muscle wasting diseases.

How does CTF1 interact with the JAK/STAT signaling pathway in different cell types?

CTF1 activates the JAK/STAT signaling pathway, affecting cell growth, differentiation, and survival.

What is the impact of CTF1 in inflammatory responses and autoimmune diseases?

CTF1 influences inflammatory and immune responses, potentially impacting autoimmune disease mechanisms.