Recombinant Human protein kinase, AMP-activated, beta 2 non-catalytic subunit, His-tagged
Cat.No. : | PRKAB2-378H |
Product Overview : | PRKAB2, 1-272aa, Human, His tag, E.coli |
- Specification
- Gene Information
- Related Products
Description : | PRKAB2 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. PRKAB2 may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Recombinant human PRKAB2 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
Source : | E.coli |
Species : | Human |
Tag : | His-tag |
Form : | Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 2M Urea |
Molecular Mass : | 32.8 kDa(296aa) |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSHMGNTTS DRVSGERHGA KAARSEGAGG HAPGKEHKIM VGSTDDPSVF SLPDSKLPGD KEFVSWQQDL EDSVKPTQQA RPTVIRWSEG GKEVFISGSF NNWSTKIPLI KSHNDFVAIL DLPEGEHQYK FFVDGQWVHD PSEPVVTSQL GTINNLIHVK KSDFEVFDAL KLDSMESSET SCRDLSSSPP GPYGQEMYAF RSEERFKSPP ILPPHLLQVI LNKDTNISCD PALLPEPNHV MLNHLYALSI KDSVMVLSAT HRYKKKYVTT LLYKPI |
Purity : | >90% by SDS - PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 1.0 mg/ml (determined by Bradford assay) |
Gene Name : | PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit [ Homo sapiens ] |
Official Symbol : | PRKAB2 |
Synonyms : | PRKAB2; protein kinase, AMP-activated, beta 2 non-catalytic subunit; 5-AMP-activated protein kinase subunit beta-2; AMPK beta 2; AMPK beta-2 chain; AMPK subunit beta-2; 5-AMP-activated protein kinase, beta-2 subunit; MGC61468; |
Gene ID : | 5565 |
mRNA Refseq : | NM_005399 |
Protein Refseq : | NP_005390 |
MIM : | 602741 |
UniProt ID : | O43741 |
Chromosome Location : | 1q21.2 |
Pathway : | AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem; AMPK signaling, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Energy Metabolism, organism-specific biosystem; Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; |
Function : | contributes_to AMP-activated protein kinase activity; AMP-activated protein kinase activity; identical protein binding; protein binding; protein kinase binding; |
Products Types
◆ Recombinant Protein | ||
PRKAB2-0733H | Recombinant Human PRKAB2 Protein (G2-I272), Tag Free | +Inquiry |
PRKAB2-4330R | Recombinant Rat PRKAB2 Protein, His (Fc)-Avi-tagged | +Inquiry |
PRKAB2-427H | Recombinant Human PRKAB2 Protein, His-tagged | +Inquiry |
PRKAB2-7085M | Recombinant Mouse PRKAB2 Protein, His (Fc)-Avi-tagged | +Inquiry |
PRKAB2-0734H | Recombinant Human PRKAB2 Protein (G2-I272), His tagged | +Inquiry |
◆ Lysates | ||
PRKAB2-1414HCL | Recombinant Human PRKAB2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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