Active Recombinant Human XCL1,HIgG1 Fc-tagged

• Cat.No.: XCL1-001H
• Product Overview: The extracellular domain of human XCL1 (AAH70309.1) (Val22-Gly114) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell

Specification

• Description: This gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1
• Source: CHO cells
• Species: Human
• Tag: HIgG1 Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to chemoattract BaF3 mouse pro B cells.
• AA Sequence: Val22-Gly114
• Endotoxin: <0.06 eu/μg as determined by lal>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: XCL1 chemokine (C motif) ligand 1 [ Homo sapiens ]
• Official Symbol: XCL1
• Synonyms: XCL1; chemokine (C motif) ligand 1; LTN, SCYC1, small inducible cytokine subfamily C, member 1 (lymphotactin); lymphotactin; ATAC; LPTN; SCM 1; SCM 1a; SCM-1-alpha; lymphotaxin; cytokine SCM-1; c motif chemokine 1; XC chemokine ligand 1; single cysteine motif 1a; small-inducible cytokine C1; small inducible cytokine subfamily C, member 1 (lymphotactin); LTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a
• Gene ID: 6375
• mRNA Refseq: NM_002995
• Protein Refseq: NP_002986
• MIM: 600250
• UniProt ID: P47992
• Chromosome Location: 1q24.2
• Pathway: Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (q) signalling events, organism-specific biosystem
• Function: chemokine activity; chemokine receptor binding; chemokine receptor binding; protein homodimerization activity

Reviews

03/30/2022

Consistent high quality, responsive customer service, and seamless delivery

07/10/2019

Commendable product quality, professional customer service, and punctual delivery.

09/05/2018

Outstanding product quality, swift delivery, and helpful customer service. Highly recommend!

Q&As

What is known about the regulation of XCL1 expression, and how do various stimuli modulate its secretion in the context of inflammatory responses and immune activation?

XCL1 expression is regulated by various stimuli, including inflammatory signals. Understanding how these stimuli modulate XCL1 secretion provides insights into its dynamic role in immune activation.

How does XCL1 influence the differentiation and function of dendritic cells, and are there implications for the modulation of adaptive immune responses?

XCL1 influences the differentiation and function of dendritic cells, affecting the priming and activation of T cells. Understanding these processes has implications for modulating adaptive immune responses in various contexts.

How does XCL1 contribute to the formation of immune synapses between dendritic cells and T cells, and what molecular events underlie this process?

XCL1 is involved in the formation of immune synapses between dendritic cells and T cells. Molecular events include the coordinated expression of adhesion molecules and the release of other signaling molecules.

Can you discuss the molecular mechanisms through which XCL1 interacts with its receptor XCR1, and how this interaction influences immune cell function?

XCL1 binds to its receptor XCR1, initiating intracellular signaling cascades. This interaction influences immune cell function by directing the migration and activation of specific immune cell subsets.

In infectious diseases, particularly viral infections, what evidence supports the involvement of XCL1 in the host immune response, and how might it influence the outcome of infections?

XCL1 is implicated in the host immune response to viral infections. Its role in recruiting and activating immune cells may influence the outcome of infections, impacting viral clearance and immune memory.