Active Recombinant Human CD200, HIgG1 Fc-tagged

• Cat.No.: CD200-101H
• Product Overview: The extracellular domain of human CD200 (AAH31103.1)(Gln31-Ser236) is fused to the N-terminus of the Fc region of human IgG1was expressed in CHO cell

Specification

• Description: The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene
• Source: CHO cells
• Species: Human
• Tag: HIgG1 Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its binding ability in a functional ELISA.
• Molecular Mass: 48KDa (monomer)
• AA Sequence: Gln31-Ser236
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: CD200 CD200 molecule [ Homo sapiens ]
• Official Symbol: CD200
• Synonyms: CD200; CD200 molecule; antigen identified by monoclonal MRC OX 2 , CD200 antigen , MOX1, MOX2; OX-2 membrane glycoprotein; MRC; OX 2; CD200 antigen; MRC OX-2 antigen; antigen identified by monoclonal MRC OX-2; MOX1; MOX2; OX-2
• Gene ID: 4345
• mRNA Refseq: NM_001004196
• Protein Refseq: NP_001004196
• MIM: 155970
• UniProt ID: P41217
• Chromosome Location: 3
• Pathway: Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem
• Function: identical protein binding; protein binding

Reviews

08/01/2022

Swift protein sequencing, helps identify unknown proteins.

05/04/2022

Great protein crystallization services, key for structural biology.

05/02/2019

Invaluable protein-protein interaction assays, integral for research.

Q&As

How does CD200 contribute to the regulation of bone marrow and hematopoietic stem cell niches?

CD200 regulates bone marrow and hematopoietic environments, supporting stem cell maintenance and differentiation.

How does CD200 influence tumor immune evasion and the tumor microenvironment in cancer?

CD200 contributes to immune evasion in cancers, affecting tumor progression and response to immunotherapy.

What role does CD200 play in the suppression of inflammatory responses in autoimmune diseases?

CD200 plays a role in suppressing inflammatory responses, which is crucial in autoimmune disease management.

What are the effects of CD200 dysregulation on tissue graft rejection and transplant tolerance?

Dysregulation of CD200 affects tissue graft rejection, influencing transplant tolerance and success.

How do alterations in CD200 expression impact the aging process and age-related immune changes?

Changes in CD200 expression impact the aging immune system, affecting age-related immune regulation and function.

What is the impact of CD200 expression on neuroinflammatory processes and neurodegenerative diseases?

CD200 expression influences neuroinflammatory processes, potentially impacting neurodegenerative diseases.

How does CD200 interact with its receptor CD200R, and what are the implications for immune regulation?

CD200 interacts with CD200R to modulate immune responses, promoting immune tolerance and reducing inflammation.