Recombinant Human NCL cell lysate

• Cat.No.: NCL-1174HCL

Specification

• Description: Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: NCL nucleolin [ Homo sapiens ]
• Official Symbol: NCL
• Synonyms: NCL; nucleolin; C23; FLJ45706; FLJ59041
• Gene ID: 4691
• mRNA Refseq: NM_005381
• Protein Refseq: NP_005372
• MIM: 164035
• UniProt ID: P19338
• Chromosome Location: 2q12-qter
• Pathway: Aurora B signaling, organism-specific biosystem; Pathogenic Escherichia coli infection, organism-specific biosystem; Pathogenic Escherichia coli infection, conserved biosystem; Regulation of Telomerase, organism-specific biosystem; T Cell Receptor Signaling Pathway, organism-specific biosystem; Validated targets of C-MYC transcriptional activation, organism-specific biosystem
• Function: DNA binding; RNA binding; nucleic acid binding; nucleotide binding; protein C-terminus binding; protein binding; telomeric DNA binding

Reviews

11/28/2022

The company provides one-stop service, from the purchase of products to the completion of experiments in one go.

07/14/2022

The protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.

12/26/2021

The staff had a good attitude, actively communicated with me and solved many technical problems.

Q&As

Where is NCL primarily located?

NCL is mainly localized in the nucleus.

What diseases is NCL involved in?

NCL is closely related to the study of diseases such as nasopharyngeal cancer and endometrial cancer.

What are the components of NCL?

The NCL consists of three parts: a nuclear localization signal, an RNA binding domain, and RGG or GAR structural domains.

What are the effects of overexpressing NCL?

Overexpression of NCL increases PCV2 viral load in cells.

What biological processes are NCL involved in?

NCL is involved in the regulation of various physiological stages such as cell proliferation, differentiation, and embryogenesis.