Recombinant Human PKN1 cell lysate
Cat.No. : | PKN1-1363HCL |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | PKN1 protein kinase N1 [ Homo sapiens ] |
Official Symbol : | PKN1 |
Synonyms : | PKN1; protein kinase N1; PRKCL1, protein kinase C like 1; serine/threonine-protein kinase N1; DBK; MGC46204; PAK1; PKN; PRK1; protein kinase C-like 1; protein kinase PKN-alpha; protein kinase C-like PKN; serine-threonine kinase N; protease-activated kinase 1; protein kinase C-related kinase 1; protein-kinase C-related kinase 1; serine-threonine protein kinase N; serine/threonine protein kinase N; PAK-1; PRKCL1; PKN-ALPHA; |
Gene ID : | 5585 |
mRNA Refseq : | NM_002741 |
Protein Refseq : | NP_002732 |
MIM : | 601032 |
UniProt ID : | Q16512 |
Chromosome Location : | 19p13.12 |
Pathway : | G13 Signaling Pathway, organism-specific biosystem; Regulation of Androgen receptor activity, organism-specific biosystem; RhoA signaling pathway, organism-specific biosystem; Salmonella infection, organism-specific biosystem; Salmonella infection, conserved biosystem; Signaling mediated by p38-gamma and p38-delta, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem; |
Function : | ATP binding; GTP-Rho binding; Rac GTPase binding; androgen receptor binding; chromatin binding; histone binding; histone deacetylase binding; histone kinase activity (H3-T11 specific); ligand-dependent nuclear receptor transcription coactivator activity; ligand-dependent nuclear receptor transcription coactivator activity; nucleotide binding; protein binding; protein kinase C activity; protein kinase C binding; protein kinase activity; protein serine/threonine kinase activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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