Native Human Dipeptidyl Peptidase IV

• Cat.No.: DPP4-197H

Specification

• Description: Dipeptidyl Peptidase IV is a lymphocyte cell surface antigen which is increased during T-cell activation and is also expressed in other tissues, such as placenta, kidney, etc. It is an atypical serine protease which has been implicated in a variety of biological functions including diabetes, rheumatoid arthritis, T-cell activation, cell-to-cell adhesion, and recently in HIV infection.
• Source: Human Placenta
• Species: Human
• Form: Frozen
• Molecular Mass: MW: 350,000
• Purity: >= 95% by SDS-PAGE
• Unit Definition: One unit is defined as the amount of enzyme which will hydrolyze one umole of H-Gly-Pro-pNA per minute at 25°C, pH 7.8
• Usage: For research use or for use in further manufacturing.
• Quality Control Test: Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
• Stability: >1 year
• Storage: <=>
• Storage Buffer: 2 mM Tris-HCI, pH 8.0

Gene Information

• Gene Name: DPP4 dipeptidyl-peptidase 4 [ Homo sapiens ]
• Official Symbol: DPP4
• Synonyms: DPP4; dipeptidyl-peptidase 4; ADCP2, adenosine deaminase complexing protein 2 , CD26, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); dipeptidyl peptidase 4; DPPIV; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV
• Gene ID: 1803
• mRNA Refseq: NM_001935
• Protein Refseq: NP_001926
• MIM: 102720
• UniProt ID: P27487
• Chromosome Location: 2q23-qter
• Pathway: Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem; Regulation of Insulin Secretion, organism-specific biosystem; Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystem
• Function: aminopeptidase activity; collagen binding; dipeptidyl-peptidase activity; peptidase activity; peptide binding; protease binding; protein binding; protein homodimerization activity; receptor activity; receptor binding; serine-type endopeptidase activity; serine-type peptidase activity