Active Native Bovine Factor IX
Cat.No. : | F9-266B |
- Specification
- Gene Information
- Related Products
Description : | The zymogen factor IX is a single chain vitamin K-dependent glycoprotein which is synthesized in the liver. The domain structure of factor IX is similar to that of the other vitamin K dependent coagulation factors. The NH2-terminal region contains 12 γ-carboxyglutamic acid (gla) residues which facilitate the calcium dependent binding of factor IX to negatively charged phospholipid surfaces. Two domains which are homologous to epidermal growth factor (EGF) span the region between the NH2-terminal gla domain and the activation peptide (Ala-146 to Arg-180). Factor IX is activated by either factor XIa or the factor VIIa/tissue factor/phospholipid complex. Cleavage at site A (see figure) yields the intermediate IXa which is subsequently converted to the fully active form IXaβ by cleavage at site B. The NH2-terminal light chain (GLA and EGF domains) remains covalently attached to the COOH-terminal heavy chain by a disulfide bond. The serine protease catalytic triad (Ser-365, His 221, Asp-269) is located in the heavy chain. Factor IXaβ is the catalytic component of the "intrinsic factor Xase complex" (factor VIIIa/IXa/Ca2+/phospholipid) which proteolytically activates factor X to factor Xa. |
Source : | Plasma |
Species : | Bovine |
Form : | 50% (vol/vol) glycerol/H2O |
Bio-activity : | Clotting assay |
Molecular Mass : | 55400 |
Purity : | >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin. |
Characteristic : | Extinction coefficient:12.0, Isoelectric point:3.7, Percent carbohydrate:0.26, Structure:single chain, NH2-terminal gla-domain, two EGF domains |
Storage : | -20°C |
Gene Name : | F9 coagulation factor IX [ Bos taurus ] |
Official Symbol : | F9 |
Synonyms : | coagulation factor I; Xchristmas factor; plasma thromboplastic component; coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) |
Gene ID : | 280688 |
mRNA Refseq : | NM_001103220 |
Protein Refseq : | NP_001096690 |
Chromosome Location : | Xq32-q33 |
Pathway : | Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Extrinsic Pathway, organism-specific biosystem |
Function : | calcium ion binding; serine-type endopeptidase activity |
Products Types
◆ Recombinant Protein | ||
F9-914R | Recombinant Rabbit F9 Protein, His-tagged | +Inquiry |
F9-915R | Recombinant Rabbit F9 Protein, His-tagged | +Inquiry |
F9-013H | Active Recombinant Human F9 Protein, His-tagged | +Inquiry |
F9-1838R | Recombinant Rat F9 Protein, His (Fc)-Avi-tagged | +Inquiry |
F9-3626H | Recombinant Human F9 Protein, GST-tagged | +Inquiry |
◆ Native Protein | ||
F9-301R | Native Rat Factor IXa | +Inquiry |
F9-671H | Native Human Coagulation Factor IX | +Inquiry |
F9-26523H | Active Native Human F9 Protein | +Inquiry |
◆ Lysates | ||
F9-1768MCL | Recombinant Mouse F9 cell lysate | +Inquiry |
F9-1849HCL | Recombinant Human F9 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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