Recombinant Human SP3, MYC/DDK-tagged

• Cat.No.: SP3-104H
• Product Overview: Recombinant Human SP3, fused to C-terminal MYC/DDK, was expressed in HEK293 cells.

Specification

• Description: This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13.
• Source: HEK293 cells
• Species: Human
• Tag: MYC/DDK
• Molecular Mass: 81.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: SP3 Sp3 transcription factor [ Homo sapiens (human) ]
• Official Symbol: SP3
• Synonyms: Sp3 transcription factor; SP3; SPR2; DKFZp686O1631; SPR-2; specificity protein 3; GC-binding transcription factor Sp3; DKFZp686O1631
• Gene ID: 6670
• mRNA Refseq: NM_003111
• Protein Refseq: NP_003102
• MIM: 601804
• UniProt ID: Q02447
• Chromosome Location: 2q31
• Pathway: Regulation of Telomerase; SIDS Susceptibility Pathways; Selenium Metabolism and Selenoproteins
• Function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter sequence-specific DNA binding; chromatin binding