Member of a serine esterase family that hydrolyze ester and amide bonds. Carboxylesterase 2 is an endoplasmic reticulum-bound hydrolase that plays a critical role in xenobiotic detoxification and activation for ester-containing therapeutics. Carboxylesterase 2 is also involved in the detoxification of drugs such as heroin and cocaine. This enzyme is thought to play a role in lipid metabolism.Carboxylesterase 2 human identifies the site containing a large alcohol and small acyl group. It shows less transesterification activity due to presence of conformational interference in active site.
Molecular Mass :
It has two glycosylation sites at 103 and 267 residues with molecular mass 60kDa.
Applications :
Carboxylesterase 2 may play a key role in biotransformation of a variety of ester containing drugs and prodrugs.
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