Active Recombinant Human Histone Deacetylase 1, His-tagged

• Cat.No.: HDAC1-392H
• Product Overview: HDAC1 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.Full Length Human HDAC1 – Class I, 59 kD with his tag.

Specification

• Cat. No.: HDAC1-392H
• Description: Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
• Source: HDAC3 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.
• Purity: Purified, active enzyme.
• Purification Procedure: Ni2+ Affinity Column
• Activity: 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug at pH8 at 30°C.
• Stability/Shelf-life: >6 months from date of shipment
• Buffer Composition: 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol
• Storage: –80°C
• Publication:
  Circumvention of Gefitinib Resistance by Repurposing Flunarizine via Histone Deacetylase Inhibition (2023)

Gene Information

• Gene Name: HDAC1 histone deacetylase 1 [ Homo sapiens ]
• Synonyms: HDAC1; DKFZp686H12203; GON-10; HD1; RPD3; RPD3L1; histone deacetylase 1; OTTHUMP00000008745; reduced potassium dependency, yeast homolog-like 1; DKFZp686H12203; EC 3.5.1.98.
• Gene ID: 3065
• mRNA Refseq: NM_004964
• Protein Refseq: NP_004955
• MIM: 601241
• UniProt ID: Q13547
• Chromosome Location: 1p34
• Pathway: Cell cycle; Chronic myeloid leukemia; Notch signaling pathway; Gene Expression; Signalling by NGF
• Function: enzyme binding; histone deacetylase activity; hydrolase activity; identical protein binding; transcription activator activity; transcription factor activity; transcription factor binding; transcription factor binding

Reviews

03/12/2022

The HDAC1 proteins purchased from your company is suitable for ELISA.

09/24/2021

The shipping was prompt enough for me to get into the experiment in the shortest time possible.

12/01/2020

Friendly customer service and detailed answers to all the questions I asked!

Q&As

What diseases has HDAC1 been associated with the study of?

HDAC1 is closely related to the study of diseases such as lung cancer and esophageal squamous carcinoma.

What is the relationship between HDAC1 and Adriamycin?

Adriamycin specifically reduces HDAC1 protein expression.

How is HDAC1 expressed in esophageal squamous carcinoma tissues?

HDAC1 protein is highly expressed in esophageal squamous carcinoma tissues, and its high expression correlates with the development of esophageal squamous carcinoma.

What biological function does HDAC1 have?

HDAC1 is a key enzyme in the histone deacetylation process and is involved in the regulation of histone acetylation levels.