Active Recombinant Human Histone Deacetylase 5, GST-tagged
Cat.No. : | HDAC5-396H |
Product Overview : | Full Length Human HDAC5–Class IIa, 150kD with GST tag. |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
Cat. No. : | HDAC5-396H |
Description : | Histone deacetylase 5, also known as HDAC5, is a human gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. |
Source : | HDAC5 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system. |
Purity : | Purified, active enzyme. |
Purification Procedure : | Glutathione Column |
Activity : | 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C. |
Stability/Shelf-life : | >6 months from date of shipment |
Buffer Composition : | 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol. |
Storage : | –80°C |
Publication : |
Functional interaction of histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) promotes breast cancer progression (2017)
|
Gene Name : | HDAC5 histone deacetylase 5 [ Homo sapiens ] |
Synonyms : | HDAC5; FLJ90614; HD5; NY-CO-9; HDAC5 histone deacetylase 5; histone deacetylase 5; antigen NY-CO-9; EC 3.5.1.98; KIAA0600; Antigen NY-CO-9. |
Gene ID : | 10014 |
mRNA Refseq : | NM_001015053 |
Protein Refseq : | NP_001015053 |
MIM : | 605315 |
UniProt ID : | Q9UQL6 |
Chromosome Location : | 17q21 |
Pathway : | Gene Expression |
Function : | histone deacetylase activity; hydrolase activity; specific transcriptional repressor activity; transcription corepressor activity; transcription factor binding |
Products Types
◆ Recombinant Protein | ||
HDAC5-4647H | Recombinant Human HDAC5 Protein, GST-tagged | +Inquiry |
HDAC5-164H | Recombinant Human HDAC5 Protein, His-tagged | +Inquiry |
HDAC5-48H | Recombinant Human HDAC5 Protein, His-tagged | +Inquiry |
HDAC5-312H | Active Recombinant Human HDAC5 Protein | +Inquiry |
HDAC5-1876R | Recombinant Rhesus Macaque HDAC5 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
HDAC5-5604HCL | Recombinant Human HDAC5 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1741 | HDAC5 Fluorogenic Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket