Recombinant Human PARK7, His-tagged

• Cat.No.: PARK7-114H
• Product Overview: Recombinant Human Parkinson disease (autosomal recessive, early onset) 7 (His-Tagged) produced inE.Coliis a single, non-glycosylated polypeptide chain. The protein contains 225 amino acids and has a molecular mass of 24 kDa.

Specification

• Cat. No.: PARK7-114H
• Description: The DJ-1 is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA-binding, androgen-receptor signaling and oxidative stress. Mutations in the DJ-1 are the cause of autosomal recessive early-onset Parkinson's disease 7 (Park7).
• Source: Escherichia Coli.
• Amino Acid Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASK RALVILAKGA EEMETVIPVD VMRRAGIKVT VAGLAGKDPV QCSRDVVICP DASLEDAKKE GPYDVVVLPG GNLGAQNLSE SAAVKEILKE QENRKGLIAA ICAGPTALLA HEIGFGSKVT THPLAKDKMM NGGHYTYSEN RVEKDGLILT SRGPGTSFEF ALAIVEALNG KEVAAQVKAP LVLKD.
• Physical Appearance: Sterile Filtered colorless solution.
• Formulation: The protein solution (1mg/ml) cotains 20mM Tris-HCl Ph-8 and 20% glycerol.
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Stability: DJ-1 although stable 14°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: PARK7 Parkinson disease (autosomal recessive, early onset) 7 [ Homo sapiens ]
• Synonyms: PARK7; Parkinson disease (autosomal recessive, early onset) 7; DJ1; DJ-1; FLJ27376; FLJ34360; FLJ92274; Parkinson disease protein 7; oncogene DJ1; oncogene DJ1; protein DJ-1; OTTHUMP00000001350; OTTHUMP00000001351; OTTHUMP00000001348; OTTHUMP00000001349
• Gene ID: 11315
• mRNA Refseq: NM_001123377
• Protein Refseq: NP_001116849
• UniProt ID: Q99497
• Chromosome Location: 1p36
• MIM: 602533
• Pathway: Parkinson"s disease
• Function: peroxiredoxin activity; protein binding