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Cat. No. |
AMBP-230H |
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Product
Overview |
Recombinant
Human UTI produced in Yeast is a single, glycosylated,
polypeptide. The protein contains 143 amino acids and has a
molecular mass of 20 kDa and predicted pI of 4.5.
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Description |
Urinary-Trypsin
Inhibitor is a glucoprotein proteinase inhibitor with a
molecular weight of about 67,000 derived from human urine which
inhibits the activity of trypsin, chymotrypsin, lactate, lipase,
hyaluronidase and various pancreatic enzymes. Ulinastatin is has
strong inhibition effect to various protease, sugar and fat
hydrolase. Ulinastatin precursor is proteolytically processed
into distinct functioning proteins. Uristatin gene is located on
chromosome 9 in a cluster of lipocalin genes. Bikunin localizes
cell membrane. Free uristatin and bikunin pass readily into
urine and are primarily bound to heavy chains that constitute
the proinhibitor form in plasma. Ulinastatin particularly
interacts with ORF3 protein of hepatitis E virus and in charge
for enhancing alpha microglobulin export from the hepatocyte. |
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Source |
Pichia Pastoris. |
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Amino Acid
Sequence |
AVLPQEEEGS
GGGQLVTEVT KKEDSCQLGY SAGPCMGMTS RYFYNGTSM ACETFQYGGCM
GNGNNFVTEK ECLQTCRTVA ACNLPIVRGP CRAFIQLWA FDAVKGKCVLF
PYGGCQGNGN KFYSEKECRE YCGVPGDGDE ELL |
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Physical
Appearance |
Sterile
Filtered solution. |
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Formulation |
Formulated in
1X PBS. |
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Purity |
Greater than
98.0% as determined by: (a) Analysis by RP-HPLC. (b)
Anion-exchange FPLC. |
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Biological
Activity |
Greater than
3000U/mg as measred by BAEE method. |
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Stability |
Ulinastatin
although stable at 15oC
for 2 weeks, should be stored desiccated below -18oC.
Please prevent freeze-thaw cycles. |
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Gene
Information
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Gene Name |
AMBP alpha-1-microglobulin/bikunin precursor [ Homo sapiens ] |
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Synonyms
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AMBP;
Ulinastatin; Alpha-1-microglobulin/bikunin precursor; HCP; ITI;
UTI; EDC1; HI30; ITIL; IATIL; ITILC; Bikunin; Uristatin; Protein
HC; Trypstatin; Uronic-acid-rich protein; Growth-inhibiting
protein 19; Inter-alpha-trypsin inhibitor light chain;
Complex-forming glycoprotein heterogeneous in charge;
OTTHUMP00000021967; OTTHUMP00000063975 |
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GeneID |
259 |
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mRNA Refseq |
NM_001633 |
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Protein Refseq |
NP_001624 |
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MIM |
176870 |
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UniProt ID |
P02760 |
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Chromosome
Location |
9q32-q33 |
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Function |
IgA binding;
calcium channel inhibitor activity; calcium oxalate binding;
heme binding; peptidase inhibitor activity; transporter
activity; serine-type endopeptidase inhibitor activity; protein
homodimerization activity |
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PDB rendering based on 1bik.
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Download Datasheet:
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