Recombinant Human MAGEA1

• Cat.No.: MAGEA1-157H
• Product Overview: Recombinant human melanoma antigen family A, 1 (directs expression of antigen MZ2-E) protein expressed in E.coli encodes full length amino acids.

Specification

• Cat. No.: MAGEA1-157H
• Description: Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on mormal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
• Source: E.coli.
• Formulation: 5µg/50µl purified human MAGE-1 protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
• Application And Suggested Dilutions: •ELISA •Inhibition Assays •Western Blotting.
• Characterization: MAGE-1 antibody reactive.
• Storage & Stability: Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.

Gene Information

• Gene Name: MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E) [ Homo sapiens ]
• Synonyms: melanoma antigen family A, 1 (directs expression of antigen MZ2-E); CT1.1; MAGE1; MGC9326; MAGEA1; melanoma antigen family A, 1; melanoma antigen MAGE-1; melanoma antigen family A 1; melanoma-associated antigen 1; melanoma-associated antigen MZ2-E; cancer/testis antigen family 1, member 1; MAGE1A; OTTHUMP00000025911; Antigen MZ2-E; Cancer/testis antigen 1.1; MAGE-1 antigen
• Gene ID: 4100
• mRNA Refseq: NM_004988
• Protein Refseq: NP_004979
• MIM: 300016
• UniProt ID: P43355