Recombinant Human Synaptotagmin I, GST-tagged
Cat.No. : | SYT1-437H |
Product Overview : | Recombinant Human synaptotagmin I expressed inE.coliwas cloned with a N-terminal-GST tag and a linker. It consists of the human Synaptotagmin I (residues 96-421, swissprot accession P21579). The GST-tag is cleaved during purification. The protein is mutated in the position I367T and contains a deletion of three amino acids 117A, 118L, and 119K. MW = 37.8 kDa. |
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Cat. No. : | SYT1-437H |
Description : | Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene. The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. |
Source : | Escherichia Coli. |
Purity : | > 95% by SDS-PAGE. The protein was observed as a single band migrating at amolecular weight of (< 45 kDa). |
Supplied As : | 1.0mg/ml in PBS pH7.3.The concentration is calculated from the absorbance at 280nm (e280 = 31150 M-1 cm-1). |
Characteristics : | Under the above described conditions, to avoid precipitation or protein dimerization, the product can be concentrated to a maximum of 500 μM. |
Storage : | -20ºC. The protein is stable at 4ºC for at least 2 weeks and at 25ºC for at least several hours. After initial defrost, aliquot product into individual tubes and refreeze at -20ºC. Avoid repeated freeze/defrost cycles. |
Gene Name : | SYT1 synaptotagmin I [ Homo sapiens ] |
Synonyms : | SYT1; synaptotagmin I; synaptotagmin 1; P65; SYT; SVP65; DKFZp781D2042; Synaptotagmin-1; DKFZp781D2042; OTTHUMP00000166064; SytI |
Gene ID : | 6857 |
mRNA Refseq : | NM_001135805 |
Protein Refseq : | NP_001129277 |
MIM : | 185605 |
UniProt ID : | P21579 |
Chromosome Location : | 12cen-q21 |
Pathway : | Botulinum neurotoxicity; Synaptic Transmission |
Function : | calcium ion binding; calcium-dependent protein binding; calmodulin binding; identical protein binding; low-density lipoprotein receptor binding; phosphatidylinositol binding; phospholipid binding; syntaxin-1 binding; transporter activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIn clinical practice, the expression level of SYT1 can be detected to predict the progression and prognosis of the disease, and to guide the choice of treatment regimen. For example, in the diagnosis and treatment of neurological diseases, the expression level of SYT1 can help doctors determine the type, stage and prognosis of the disease, and guide the choice of treatment regimen.
Studies have shown that SYT1 protein can participate in the regulation of antiviral immune response and affect the course of viral infection.
SYT1 protein plays an important role in the pathogenesis of certain autoimmune diseases.
Studies have shown that SYT1 protein may be associated with the pathogenesis of cardiovascular diseases such as atherosclerosis and myocardial infarction.
There is no conclusive evidence that diet can improve the nutritional status of SYT1 protein, but maintaining a balanced diet and moderate protein intake can help maintain good health.
Drug development for SYT1 is currently in clinical trials, including small molecule inhibitors against SYT1 and inhibitors against the SYT1 signaling pathway.
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