Recombinant Human IFNGR2, Fc Chimera
Cat.No. : | IFNGR2-23H |
Product Overview : | Recombinant Human IFNGR2 encoding the signal peptide and extracellular domain of human interferon gamma receptor 2 (aa 1-247) chain was fused to the Fc region of human IgG1 (aa 93-330). The chimeric protein was expressed in modifiedhuman 293 cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IFNGR2-23H |
Description : | Interferon-gamma (IFN-gamma) is a pleotropic cytokine expressed predominantly by naïve and activated CD8+ and TH1 CD4+ T cells, and natural killer (NK) cells and, as such, promotes both innate and adaptive immune responses. |
Source : | Human 293 cells. |
Amino Acid Sequence : | SQLPAPQHPKIRLYNAEQVLSWEPV ALSNSTRPVVYRVQFKYTDSKWFTA DIMSIGVNCTQITATECDFTAASPS AGFPMDFNVTLRLRAELGALHSAWV TMPWFQHYRNVTVGPPENIEVTPGE GSLIIRFSSPFDIADTSTAFFCYYV HYWEKGGIQQVKGPFRSNSISLDNL KPSRVYCLQVQAQLLWNKSNIFRVG HLSNISCYETMADASTELQQGSSNT KVDKKVEPKSCDKTHTCPPCPAPEL LGGPSVFLFPPKPKDTLMISRTPEV TCVVVDVSHEDPEVKFNWYVDGVEV HNAKTKPREEQYNSTYRVVSVLTVL HQDWLNGKEYKCKVSNKALPAPIEK TISKAKGQPREPQVYTLPPSRDELT KNQVSLTCLVKGFYPSDIAVEWESN GQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGK. |
Molecular Mass : | IFN-gamma R2 – Fc Chimera migrates as a broad band between 65 and 75 kDa on SDS-PAGE due to post-translation modifications, in particular glycosylation. This compares with the unmodified IFN-gamma R2 - Fc Chimera that has a predicted molecular mass of 52 kDa. |
pI : | IFN-gamma R2 – Fc Chimera separates into a number of glycoforms with a pI between 5.5 and 8 on 2D PAGE due to post-translational modifications, in particular glycosylation. |
% Carbohydrate : | Purified IFN-gamma R2 – Fc Chimera consists of 20-30% carbohydrate by weight. |
Glycosylation : | IFN-gamma R2 – Fc Chimera has N- and possibly O-linked oligosaccharides. |
Purity : | >95%, as determined by SDS-PAGE and visualized by Coomassie Brilliant Blue. |
Formulation : | When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose. |
Reconstitution : | It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. |
Storage : | Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended. |
Gene Name : | IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) [ Homo sapiens ] |
Synonyms : | IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1); AF-1; IFGR2; IFNGT1; Interferon-gamma receptor accessory factor 1; interferon gamma receptor accessory factor-1; Interferon-gamma transducer 1; interferon gamma receptor beta chain; interferon-gamma receptor beta chain precursor |
Gene ID : | 3460 |
mRNA Refseq : | NM_005534 |
Protein Refseq : | NP_005525 |
UniProt ID : | P38484 |
Chromosome Location : | 21q22.1 |
MIM : | 147569 |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity |
Function : | interferon-gamma receptor activity; receptor activity |
Products Types
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Ifngr2-1219M | Recombinant Mouse Ifngr2 Protein, MYC/DDK-tagged | +Inquiry |
IFNGR2-1152H | Recombinant Human IFNGR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IFNGR2-1899MCL | Recombinant Mouse IFNGR2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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