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Home > Products > Recombinant Proteins > Recombinant Human Cardiotrophin-like Cytokine Factor 1

Recombinant Human Cardiotrophin-like Cytokine Factor 1

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Human(17)
Mouse(6)
Rat(3)
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Fc(1)
His(4)
N/A(1)
Cat. No.:
CLCF1-953H
Product Overview:
Recombinant human NNT-1/BCSF-3 produced inE.Coliis a 22.4 kDa protein containing 199 amino acid residues.
Description:
NNT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, NNT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member beta (LIFR-beta) and induces tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss and B cell hyperplasia associated with increased in serum IgG and IgM.
Source:
E.Coli.
Purity:
> 98% by SDS-PAGE and HPLC analysis.
Endotoxin Level:
< 0.1 ng per μg of NNT-1/BCSF-3.
Stabilizer:
None.
Formulation:
Lyophilized.
Biological Activity:
NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/ml.
Reconstitution:
The human NNT-1/BCSF-3 should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
Stability:
The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted human NNT-1/BCSF-3 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Pathways:
Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-097-1828
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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