Recombinant Human Cardiotrophin-like Cytokine Factor 1

• Cat.No.: CLCF1-953H
• Product Overview: Recombinant human NNT-1/BCSF-3 produced inE.Coliis a 22.4 kDa protein containing 199 amino acid residues.

Specification

• Cat. No.: CLCF1-953H
• Description: NNT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, NNT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member beta (LIFR-beta) and induces tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss and B cell hyperplasia associated with increased in serum IgG and IgM.
• Source: E.Coli.
• Purity: > 98% by SDS-PAGE and HPLC analysis.
• Endotoxin Level: < 0.1 ng per μg of NNT-1/BCSF-3.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biological Activity: NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/ml.
• Reconstitution: The human NNT-1/BCSF-3 should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
• Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted human NNT-1/BCSF-3 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
• Pathways: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway

Gene Information

• Gene Name: CLCF1 cardiotrophin-like cytokine factor 1 [ Homo sapiens ]
• Synonyms: cardiotrophin-like cytokine factor 1; CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1; CLCF1; novel neurotrophin-1; B-cell stimulating factor 3; B-cell stimulatory factor 3; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3; B cell-stimulating factor 3; cold-induced sweating syndrome 2
• Gene ID: 23529
• mRNA Refseq: NM_001166212
• Protein Refseq: NP_001159684
• MIM: 607672
• UniProt ID: Q9UBD9
• Chromosome Location: 11q13.3
• Function: cytokine activity; growth factor activity

Reviews

10/25/2019

With their meticulous documentation and support, I am confident that my utilization of CLCF1 protein in clinical trials will meet all necessary regulations and guidelines.

05/07/2017

the manufacturer's supply management capabilities assure a seamless and continuous provision of the CLCF1 protein.

09/19/2016

In addition to the remarkable quality of the protein, the manufacturer's support extends beyond the provision of the product itself.

Q&As

Can CLCF1 be measured as a biomarker for certain diseases?

Research suggests that levels of CLCF1 in blood or tissues may serve as potential biomarkers for specific diseases, aiding in early diagnosis and prognosis.

How is CLCF1 production regulated in the human body?

The production of CLCF1 is tightly regulated at the transcriptional and post-translational levels, involving various signaling pathways.

Are there any clinical trials exploring the use of CLCF1 in medical interventions?

Yes, there are ongoing clinical trials investigating the therapeutic potential of CLCF1 in various diseases, including autoimmune disorders and neurodegenerative conditions.

How does CLCF1 interact with other cytokines in the IL-6 family?

CLCF1 can interact with various receptors and signaling molecules within the IL-6 cytokine family, influencing a range of physiological processes.

In what ways does CLCF1 contribute to neurodegenerative disorders?

Studies have indicated that CLCF1 may play a role in neurodegenerative conditions, and understanding its function could lead to potential therapies for diseases like Alzheimer's and Parkinson's.