Active Recombinant Human Jun Oncogene
Cat.No. : | JUN-1027H |
- Specification
- Gene Information
- Related Products
Cat. No. : | JUN-1027H |
Description : | C-Jun is the name of a gene and protein which, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. C-Jun knockout is lethal, but transgenic animals with a mutated c-Jun that cannot be phosphorylated (termed c-JunAA) can survive.The growth- promoting activity of c-jun is mediated by repression of tumor suppressors, as well as up-regulation of positive cell cycle regulators. Mostly, c-jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. Recombinant c-jun was expressed in aBaculovirussystem and purified by an affinity column in combination with FPLC chromatography. The purified recombinant protein contains no detectable protease, DNase, and RNase activity. |
Source : | Baculovirus. |
Form : | Liquid. Supplied in 20mM Tris-HCl pH8.0, 20% glycerol, 100mM KCl, 0.2mM EDTA and 1mM DTT. |
Activity : | 100ng are sufficient for a protein-protein interaction assay. |
Application : | C-fos has been applied in protein-DNA and protein-protein interaction assays. |
Purity : | >90% by SDS-PAGE. |
Usage : | For in vitro use only. |
Storage : | Quality guaranteed for 12 months. Store at -80°C. Avoid freeze / thaw cycles. |
Gene Name : | JUN jun oncogene [ Homo sapiens ] |
Synonyms : | JUN; jun oncogene; AP1; AP-1; c-Jun; activator protein 1; enhancer-binding protein AP1; Jun activation domain binding protein; v-jun sarcoma virus 17 oncogene homolog; v-jun avian sarcoma virus 17 oncogene homolog |
Gene ID : | 3725 |
mRNA Refseq : | NM_002228 |
Protein Refseq : | NP_002219 |
MIM : | 165160 |
UniProt ID : | P05412 |
Chromosome Location : | 1p32-p31 |
Pathway : | B cell receptor signaling pathway; Colorectal cancer; Epithelial cell signaling in Helicobacter pylori infection; ErbB signaling pathway; Focal adhesion; GnRH signaling pathway; MAPK signaling pathway; Neurotrophin signaling pathway; Pathways in cancer; Renal cell carcinoma; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Wnt signaling pathway; Signaling in Immune system |
Function : | R-SMAD binding; RNA polymerase II transcription factor activity; Rho GTPase activator activity; double-stranded DNA binding; promoter binding; protein dimerization activity; transcription factor activity; transcription factor binding |
Products Types
◆ Recombinant Protein | ||
JUN-4693M | Recombinant Mouse JUN Protein, His (Fc)-Avi-tagged | +Inquiry |
JUN-2156R | Recombinant Rhesus Macaque JUN Protein, His (Fc)-Avi-tagged | +Inquiry |
JUN-2802R | Recombinant Rat JUN Protein, His (Fc)-Avi-tagged | +Inquiry |
JUN-2945C | Recombinant Chicken JUN | +Inquiry |
JUN-8438M | Recombinant Mouse JUN Protein | +Inquiry |
◆ Lysates | ||
JUN-5095HCL | Recombinant Human JUN 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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