Diamine Acetyltransferase 1

Cat. No.

CBCRY21

Background

Spermidine/spermine N(1)-acetyltransferase (SSAT; EC 2.3.1.57) is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the N(1)-acetylation of spermidine and spermine and, by the successive activity of polyamine oxidase, spermine can be converted to spermidine and spermidine to putrescine.

Molecular description

Protein Classification

Transferase

Structure Weight

42238.60 Da

Polymer

1

Molecule

Diamine acetyltransferase 1

Chain Length

179 amino acids

Crystal Description

PDB ID

2G3T

MMDB ID

38382

Source

E.coli

Method

X-Ray Diffraction

Resolution

1.8?

Gene information

Gene Name

SAT1

Synonyms

DC21; EC 2.3.1.57; KFSD; SAT; SSAT; SSAT-1;OTTHUMP00000023061; diamine N-acetyltransferase 1; diamine acetyltransferase 1; spermidine/spermine N1-acetyltransferase alpha; spermidine/spermine N1-acetyltransferase 1; Polyamine N-acetyltransferase 1; Putrescine acetyltransferase

UniProt ID

P21673

GeneID

6303

Chromosome  Location

Xp22.1

Function

acyltransferase activity; diamine N-acetyltransferase activity; transferase activity

Reference

Zhu, Y.Q.,  Zhu, D.Y.,  Yin, L.,  Zhang, Y.,  Vonrhein, C.,  Wang, D.C. (2006) Crystal structure of human spermidine/spermine N1-acetyltransferase (hSSAT): the first structure of a new sequence family of transferase homologous superfamily Proteins 63: 1127-1131