Pyrroline-5-carboxylate Reductase 2

• Cat.No.: CBCRY25

Specification

• Cat. No.: CBCRY25
• Background: Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymatic cycle between P5C and proline is very important for the regulation of amino acid metabolism, intracellular redox potential, and apoptosis.
• Protein Classification: Oxidoreductase
• Structure Weight: 149791.08 Da
• Polymer: 1
• Molecule: Pyrroline-5-carboxylate reductase 2
• Chain Length: 277 amino acids
• PDB ID: 2GR9
• MMDB ID: 41570
• Source: E.coli
• Method: X-Ray Diffraction
• Resolution: 3.1Å
• Ligand Chemical Component: Magnesium ion; Sulfate ion
• Reference: Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z. (2006) Crystal structure of human pyrroline-5-carboxylate reductase J.Mol.Biol. 359: 1364-1377

Gene Information

• Gene Name: PYCR2
• Synonyms: P5CR2; OTTHUMP00000035614; pyrroline 5-carboxylate reductase isoform; EC 1.5.1.2; P5C reductase 2; pyrroline-5-carboxylate reductase family, member 2; FLJ54750; RP4-559A3.4
• UniProt ID: Q96C36
• Gene ID: 29920
• Chromosome Location: 1q42.12
• Function: catalytic activity; binding; pyrroline-5-carboxylate reductase activity; Oxidoreductase activity