Serum Albumin

Cat. No.: CBCRY36
Background: 3"-Azido-3"-deoxythymidine (AZT) is the first clinically effective drug for the treatment of human immunodeficiency virus infection. The drug interaction with human serum albumin (HSA) has been an important component in understanding its mechanism of action, especially in drug distribution and in drug-drug interaction on HSA in the case of multi-drug therapy.
Protein Classification: Lipid binding protein
Structure Weight: 68485.53 Da
Polymer: 1
Molecule: Serum albumin
Chain Length: 585 amino acids
PDB ID: 3B9M
MMDB ID: 64671
Source: E.coli
Method: X-Ray Diffraction
Resolution: 2.70Å
Ligand Chemical Component: AZZ; Myristic acid; 2-hydroxybenzoic acid
Reference: Zhu, L., Yang, F., Chen, L., Meehan, E.J., Huang, M. (2008) A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography J.Struct.Biol. 162: 40-49
Gene Name: ALB
Synonyms: DKFZp779N1935; PRO0883; PRO0903; PRO1341; cell growth inhibiting protein 42; growth-inhibiting protein 20; serum albumin
UniProt ID: P02768
Gene ID: 213
Chromosome Location: 4q11-q13
Function: DNA binding; fatty acid binding; copper ion binding; protein binding; drug binding; lipid binding; toxin binding; antioxidant activity; oxygen binding; pyridoxal phosphate binding; metal ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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