Recombinant Human EPH Receptor A4, GST-tagged, Active

• Cat.No.: EPHA4-302H
• Product Overview: Recombinant human EPHA4 (610-887) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=58kDa.

Specification

• Cat. No.: EPHA4-302H
• Description: EPHA4 also known as EPH receptor A4, belongs to the ephrin receptor subfamily of protein-tyrosine kinases which have been implicated in mediating developmental events, particularly in the nervous system. The EPHA4 ligand ephrin-A3 is localized to the astrocytic processes that envelop the spine. Activation of EPHA4 by ephrin-A3 induces spinal retraction and reduces spine density and inhibits the interaction distorted spine shape and organization. EPHA4-null mice possess defects in the corticospinal tract and anterior commissure indicating a model in which an ephrin ligand on the axons senses EPHA4 on spinal cord cells surrounding the corticospinal tract.
• Source: Sf9 insect cellsusing baculovirus.
• Sequence: 610-887.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: EPHA4 EPH receptor A4 [ Homo sapiens ]
• Synonyms: EPHA4; EPH receptor A4; SEK; HEK8; TYRO1; OTTHUMP00000164185; TYRO1 protein tyrosine kinase; ephrin receptor EphA4; ephrin type-A receptor 4; receptor protein-tyrosine kinase HEK8; tyrosine-protein kinase receptor SEK; EC 2.7.10.1
• Gene ID: 2043
• mRNA Refseq: NM_004438
• Protein Refseq: NP_004429
• MIM: 602188
• UniProt ID: P54764
• Chromosome Location: 2q36.1
• Pathway: Axon guidance
• Function: ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity; transferase activity