Recombinant Human ANXA1, His-tagged

• Cat.No.: ANXA1-26347TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-346 of Human Annexin A1 with His tag.

Specification

• Description: Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity.Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Storage buffer: Preservative: 100mM ImidazoleConstituents: 0.5M Sodium chloride, 20mM Tris HCl, 1mM Beta mercaptoethanol, pH 8
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the annexin family.Contains 4 annexin repeats.

Gene Information

• Gene Name: ANXA1 annexin A1 [ Homo sapiens ]
• Official Symbol: ANXA1
• Synonyms: ANXA1; annexin A1; ANX1, LPC1
• Gene ID: 301
• mRNA Refseq: NM_000700
• Protein Refseq: NP_000691
• MIM: 151690
• Uniprot ID: P04083
• Chromosome Location: 9q21.13
• Pathway: Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem
• Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; phospholipase inhibitor activity