Recombinant Human CA2

• Cat.No.: CA2-27265TH
• Product Overview: Recombinant full length Human Carbonic Anhydrase II, Predicted MWt 29 kDa.

Specification

• Description: CA2 is one of several (at least 7) isozymes of carbonic anhydrase.Carbonic anhydrase catalyzes reversible hydration of carbon dioxide.Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis.
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 50mM Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MSHHWGYGKH NGPEHWHKDF PIAKGERQSP VDIDTHTAKY DPSLKPLSVS YDQATSLRIL NNGHAFNVEF DDSQDKAVLK GGPLDGTYRL IQFHFHWGSL DGQGSEHTVD KKKYAAELHL VHWNTKYGDF GKAVQQPDGL AVLGIFLKVG SAKPGLQKVV DVLDSIKTKG KSADFTNFDP RGLLPESLDY WTYPGSLTTP PLLECVTWIV LKEPISVSSE QVLKFRKLNF NGEGEPEELM VDNWRPAQPL KNRQIKASFK
• Sequence Similarities: Belongs to the alpha-carbonic anhydrase family.

Gene Information

• Gene Name: CA2 carbonic anhydrase II [ Homo sapiens ]
• Official Symbol: CA2
• Synonyms: CA2; carbonic anhydrase II; carbonic anhydrase 2; CA II; CAII; Car2
• Gene ID: 760
• mRNA Refseq: NM_000067
• Protein Refseq: NP_000058
• MIM: 611492
• Uniprot ID: P00918
• Chromosome Location: 8q22
• Pathway: Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Collecting duct acid secretion, organism-specific biosystem; Collecting duct acid secretion, conserved biosystem; Gastric acid secretion, organism-specific biosystem
• Function: carbonate dehydratase activity; lyase activity; metal ion binding; zinc ion binding

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08/30/2021

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Q&As

Is CA2 involved in any particular pathological conditions?

CA2 deficiency is a rare autosomal recessive disorder with metabolic acidosis and osteopetrosis.

What are the known inhibitors of CA2 and their clinical implications?

Acetazolamide is a known inhibitor, used clinically for glaucoma and altitude sickness.

How do mutations in the CA2 gene influence enzyme activity or stability?

Some mutations can lead to CA2 deficiency, affecting acid-base balance and leading to metabolic acidosis.

How does CA2's enzymatic activity compare to other carbonic anhydrase isoforms?

CA2 is one of the most efficient and fastest enzymes, displaying higher activity than many other isoforms.

What role does CA2 play in the physiological regulation of pH?

CA2 accelerates the reversible conversion of CO2 and water to bicarbonate and protons, aiding in pH regulation.

Are there specific cellular pathways where CA2 plays a significant role?

CA2 plays a crucial role in CO2 transport and acid-base balance in various tissues.

How is CA2 expression distributed across different human tissues?

CA2 is ubiquitously expressed but is particularly abundant in red blood cells and certain epithelial tissues.