Recombinant Human CDKN1B, GST-tagged

• Cat.No.: CDKN1B-1478H
• Product Overview: Recombinant full-length human p27KIP1 was expressed inE. colicells using a N-terminal GST tag. MW = 52 kDa.

Specification

• Cat. No.: CDKN1B-1478H
• Description: KIP1 (cyclin-dependent kinase inhibitor 1B) is a kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation. Many tumorigenic processes modulate cell-cycle progression by regulating the levels of the cyclin-dependent kinase inhibitor KIP1. KIP1 binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4. The phosphorylation- and ubiquitination-dependent proteolysis of KIP1 is implicated in control of the G1-S transition in the cell cycle. KIP1 is critical for retinoblastoma protein (Rb)-induced cellular proliferative senescence.
• Source: E. coli.
• Sequence: Full-length
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) [ Homo sapiens ]
• Synonyms: CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); KIP1; MEN4; CDKN4; MEN1B; P27KIP1; cyclin -dependent kinase inhibitor 1B; p27Kip1; Cyclin-dependent kinase inhibitor p27
• Gene ID: 1027
• mRNA Refseq: NM_004064
• Protein Refseq: NP_004055
• MIM: 600778
• UniProt ID: P46527
• Chromosome Location: 12p13.1-p12
• Pathway: Cell cycle; Chronic myeloid leukemia; ErbB signaling pathway; Pathways in cancer; Prostate cancer; Small cell lung cancer
• Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase inhibitor activity; transforming growth factor beta receptor, cytoplasmic mediator activity