Recombinant Human CHD4

• Cat.No.: CHD4-27065TH
• Product Overview: Recombinant fragment of Human CHD4 protein with an N terminal proprietary tag; predicted MWt: 36.52 kDa inclusive of tag.

Specification

• Description: The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
• Protein length: 99 amino acids
• Molecular Weight: 36.520kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: ETEPKGAADVEKVEEKSAIDLTPIV VEDKEEKKEEEEKKEVMLQNGETPK DLNDEKQKKNIKQRFMFNIADGGFT ELHSLWQNEERAATVTKKTYEIWH
• Sequence Similarities: Belongs to the SNF2/RAD54 helicase family.Contains 2 chromo domains.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain.Contains 2 PHD-type zinc fingers.

Gene Information

• Gene Name: CHD4 chromodomain helicase DNA binding protein 4 [ Homo sapiens ]
• Official Symbol: CHD4
• Synonyms: CHD4; chromodomain helicase DNA binding protein 4; chromodomain-helicase-DNA-binding protein 4; Mi 2b; Mi2 BETA
• Gene ID: 1108
• mRNA Refseq: NM_001273
• Protein Refseq: NP_001264
• MIM: 603277
• Uniprot ID: Q14839
• Chromosome Location: 12p13
• Pathway: Signaling events mediated by HDAC Class I, organism-specific biosystem
• Function: ATP binding; ATP-dependent DNA helicase activity; DNA binding; helicase activity; hydrolase activity

Reviews

12/10/2022

Efficient and precise, a cornerstone of our research.

02/27/2022

Dependable partner, trusted for data accuracy.

10/22/2020

Key to our research success, supports research consistency.

Q&As

How does CHD4 interact with other components of the chromatin remodeling complex?

CHD4 collaborates with the NuRD complex in chromatin remodeling.

What role does CHD4 play in gene regulation?

CHD4 regulates gene transcription via chromatin accessibility.

What is the primary role of CHD4 in chromatin remodeling?

CHD4 alters chromatin structure, aiding in DNA accessibility.

How do genetic variations in CHD4 affect gene expression?

Genetic changes in CHD4 affect gene expression and cellular function.

What is the impact of altered CHD4 activity on cancer development?

Altered CHD4 activity is associated with cancer progression.

How does CHD4 contribute to DNA damage repair?

It remodels chromatin for efficient DNA repair.

What potential therapeutic applications arise from targeting CHD4 in cancer treatment?

Targeting CHD4 offers potential cancer treatment strategies by affecting cell growth.