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Home > Products > Recombinant Proteins > Recombinant Human ITGA4 protein, His-tagged

Recombinant Human ITGA4 protein, His-tagged

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By Species
Human(8)
Mouse(7)
Rat(4)
By Tag
His(3)
Human(3)
Cat.No.:
ITGA4-1541H
Product Overview:
Recombinant Human ITGA4(aa 131 - 275) fused with His tag at N-terminal was expressed in E. coli.
Description:
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha 4 chain associates with either beta 1 or beta 7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin 41 and 47 is located on the 4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin a4b7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin 47, the gut mucosal homing receptor for peripheral T cells. This recombinant protein fragment includes the ligand and monoclonal antibody binding domains; this binding has been tested and verified in ELISA assays. This recombinant protein is recognized PSI antibodies Integrin 4 (IN1) and Integrin 4 (IN2), but not Integrin 4 (CT)).
Source:
E. coli
Species:
Human
Tag:
His
Form:
50mM Tris pH7.5, 150mM NaCl, 5 mM MgCl2
Molecular Mass:
17 kDa (Calculated)
Purity:
~95%
Applications:
ELISA, WB. This recombinant protein can be used for WB and ELISA.
Notes:
For research use only.
Storage:
Store in working aliquots at -70 centigrade. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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