Recombinant Human FCER1A, GST-tagged

• Cat.No.: FCER1A-28166TH
• Product Overview: Recombinant Human FCER1A (1 a.a. - 257 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ.

Specification

• Description: The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit.
• Source: Wheat germ
• Species: Human
• Tag: GST
• Molecular Mass: 54.01 kDa
• AA Sequence: MAPAMESPTLLCVALLFFAPDGVLA VPQKPKVSLNPPWNRIFKGENVTLT CNGNNFFEVSSTKWFHNGSLSEETN SSLNIVNAKFEDSGEYKCQHQQVNE SEPVYLEVFSDWLLLQASAEVVMEG QPLFLRCHGWRNWDVYKVIYYKDGE ALKYWYENHNISITNATVEDSGTYY CTGKVWQLDYESEPLNITVIKAPRE KYWLQFFIPLLVVILFAVDTGLFIS TQQQVTFLLKIKRTRKGFRLLNPHP KPNPKNN
• Applications: ELISA; WB-Re; AP; Array
• Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide [ Homo sapiens (human) ]
• Official Symbol: FCER1A
• Synonyms: FCER1A; FCE1A; FcERI; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
• Gene ID: 2205
• mRNA Refseq: NM_002001
• Protein Refseq: NP_001992
• MIM: 147140
• UniProt ID: P12319
• Chromosome Location: 1q23
• Pathway: Asthma; Fc epsilon RI signaling pathway; Fc epsilon receptor (FCERI) signaling
• Function: IgE binding; IgE receptor activity

Reviews

11/30/2022

FCER1A can maintain its biological activity and structural integrity under specific experimental conditions.

11/08/2022

FCER1A quality is stable and reliable, with no significant differences between batches.

01/15/2021

FCER1A has high chemical and physical stability and is suitable for long-term storage and use.

Q&As

Is FCER1A expression regulated?

Modulation of FCER1A expression can be achieved through techniques such as gene knockout, gene silencing, or gene transduction. In addition, its expression levels can also be affected by altering environmental factors such as nutrition, inflammation, etc.

How can I detect the expression level of FCER1A?

The expression level of FCER1A can be detected by gene expression profiling or immunohistochemistry.

Is there a role for FCER1A in the immune system?

FCER1A plays a key role in the immune system, recognizing and presenting antigens to T cell receptors, thereby initiating an adaptive immune response.

What diseases is FCER1A associated with?

Studies have shown that FCER1A is associated with the risk of some autoimmune diseases, inflammatory diseases, and certain cancers.

What is the significance of studying FCER1A?

Studying FCER1A can help to gain insight into the mechanisms of immune response and inflammatory response, which is of great significance for the development of new drugs and therapeutic strategies. In addition, it is also of great value for understanding the pathogenesis and prevention of diseases.

How is FCER1A related to other genes or proteins?

FCER1A has complex associations with other genes and proteins, such as its interaction with T cell receptors, inflammatory factors, etc.