Recombinant Human IFNGR2, Fc-tagged

• Cat.No.: IFNGR2-29421TH
• Product Overview: Recombinant fragment, corresponding to the extracellular domain of Human IFN gamma Receptor beta , fused to the Fc region of Human IgG1 (aa 93-330). The chimeric protein was expressed in modified Human 293 cells.

Specification

• Description: This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
• Conjugation: Fc
• Form: Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not reco
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin
• Storage: Store at +4°C.
• Sequences of amino acids: Theoretical sequence: SQLPAPQHPKIRLYNAEQVLSWEPV ALSNSTRPVVYRV QFKYTDSKWFTADIMSIGVNCTQIT ATECDFTAASPSA GFPMDFNVTLRLRAELGALHSAWVT MPWFQHYRNVTVG PPENIEVTPGEGSLIIRFSSPFDIA DTSTAFFCYYVHY WEKGGIQQVKGPFRSNSISLDNLKP SRVYCLQVQAQLLWNKSNIFRVGHL SNISCYETMADASTELQQGSSNTKV DKK VEPKSCDKTHTCPPCPAPELLGGPS VFLFPPKPKDTLM ISRTPEVTCVVVDVSHEDPEVKFNW YVDGVEVHNAKTK PREEQYNSTYRVVSVLTVLHQDWLN GKEYKCKVSNKAL PAPIEKTISKAKGQPREPQVYTLPP SRDELTKNQVSLTCLVKGFYPSDIA VEWESNGQPENNYKTTPPVLDSDGS FFL YSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLS PGK
• Sequence Similarities: Belongs to the type II cytokine receptor family.Contains 2 fibronectin type-III domains.

Gene Information

• Gene Name: IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) [ Homo sapiens ]
• Official Symbol: IFNGR2
• Synonyms: IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1); IFNGT1; interferon gamma receptor 2; AF 1
• Gene ID: 3460
• mRNA Refseq: NM_005534
• Protein Refseq: NP_005525
• MIM: 147569
• Uniprot ID: P38484
• Chromosome Location: 21q22.1
• Pathway: Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem
• Function: interferon-gamma receptor activity; receptor activity