Active Recombinant Human IGFBP1 protein

• Cat.No.: IGFBP1-29544TH
• Product Overview: Recombinant Human IGFBP1 was expressed in E. coli.

Specification

• Description: This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
• Source: E. coli
• Species: Human
• Bio-activity: The ED50, as determined by its ability to inhibit IGF-I induced proliferation of MCF-7, is < 0.5 µg/ml in the presence of 6 ng/ml of human IGF-I.
• AA Sequence: MAPWQCAPCS AEKLALCPPV SASCSEVTRS AGCGCCPMCA LPLGAACGVA TARCARGLSC RALPGEQQPL HALTRGQGAC VQESDASAPH AAEAGSPESP ESTEITEEEL LDNFHLMAPS EEDHSILWDA ISTYDGSKAL HVTNIKKWKE PCRIELYRVV ESLAKAQETS GEEISKFYLP NCNKNGFYHS RQCETSMDGE AGLCWCVYPW NGKRIPGSPE IRGDPNCQIY FNVQN
• Endotoxin: < 0.100 Eu/µg
• Applications: Western blot; SDS-PAGE; Functional Studies
• Storage: Shipped at 4 centigrade. The lyophilized protein is stable for a few weeks at room temperature. Store at -20 centigrade long term.
• Reconstitution: Reconsitute to 1mg/ml with sterile water.

Gene Information

• Gene Name: IGFBP1 insulin-like growth factor binding protein 1 [ Homo sapiens ]
• Official Symbol: IGFBP1
• Synonyms: IGFBP1; insulin-like growth factor binding protein 1; IBP1; insulin-like growth factor-binding protein 1; AFBP; alpha pregnancy associated endometrial globulin; amniotic fluid binding protein; binding protein 25; binding protein 26; binding protein 28; growth hormone independent binding protein; hIGFBP 1; IGF binding protein 1; IGF BP25; placental protein 12; PP12; IBP-1; IGFBP-1; binding protein-25; binding protein-26; binding protein-28; IGF-binding protein 1; growth hormone independent-binding protein; alpha-pregnancy-associated endometrial globulin; IGF-BP25; hIGFBP-1
• Gene ID: 3484
• mRNA Refseq: NM_000596
• Protein Refseq: NP_000587
• MIM: 146730
• UniProt ID: P08833
• Chromosome Location: 7p13-p12
• Pathway: Activation of Genes by ATF4, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; PERK regulated gene expression, organism-specific biosystem
• Function: insulin-like growth factor binding