Recombinant Human LDLR
Cat.No. : | LDLR-29938TH |
Product Overview : | Recombinant fragment corresponding to amino acids 105-205 of Human LDL Receptor with a proprietary tag; Predicted MWt 36.74 kDa including tag. |
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Description : | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. |
Protein length : | 101 amino acids |
Molecular Weight : | 36.740kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.79% Tris HCl, 0.31% Glutathione |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | PPKTCSQDEFRCHDGKCISRQFVCD SDRDCLDGSDEASCPVLTCGPASFQ CNSSTCIPQLWACDNDPDCEDGSDE WPQRCRGLYVFQGDSSPCSAFEFHC L |
Sequence Similarities : | Belongs to the LDLR family.Contains 3 EGF-like domains.Contains 7 LDL-receptor class A domains.Contains 6 LDL-receptor class B repeats. |
Gene Name : | LDLR low density lipoprotein receptor [ Homo sapiens ] |
Official Symbol : | LDLR |
Synonyms : | LDLR; low density lipoprotein receptor; low-density lipoprotein receptor; familial hypercholesterolemia; |
Gene ID : | 3949 |
mRNA Refseq : | NM_000527 |
Protein Refseq : | NP_000518 |
Uniprot ID : | P01130 |
Chromosome Location : | 19p13.2 |
Pathway : | Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Chylomicron-mediated lipid transport, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; Endocytosis, organism-specific biosystem; |
Function : | calcium ion binding; low-density lipoprotein particle binding; low-density lipoprotein receptor activity; protein binding; receptor activity; |
Products Types
◆ Recombinant Protein | ||
LDLR-3027R | Recombinant Rat LDLR Protein, His (Fc)-Avi-tagged | +Inquiry |
LDLR-422H | Recombinant Human LDLR Protein, MYC/DDK-tagged | +Inquiry |
LDLR-345C | Recombinant Cynomolgus monkey LDLR Protein, His-tagged | +Inquiry |
Ldlr-1308M | Recombinant Mouse Ldlr Protein, MYC/DDK-tagged | +Inquiry |
LDLR-267H | Active Recombinant Human LDLR Protein, His-Avi-tagged, Biotinylated | +Inquiry |
◆ Native Protein | ||
LDLR-85H | Native Human Lipoprotein | +Inquiry |
◆ Lysates | ||
LDLR-2762MCL | Recombinant Mouse LDLR cell lysate | +Inquiry |
LDLR-2780HCL | Recombinant Human LDLR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, conditions where increasing the expression or function of LDLR could potentially aid in reducing circulating LDL cholesterol and minimizing cardiovascular risk.
Yes, research is continually conducted to better understand LDLR-related conditions and to develop more effective treatments, including gene-editing technologies and novel therapies.
Dysfunction in LDLR can lead to high levels of LDL cholesterol in the blood, contributing to conditions like familial hypercholesterolemia and an increased risk of heart disease.
A dysfunctional LDLR can lead to an accumulation of LDL cholesterol in the arteries, promoting atherosclerosis, the hardening and narrowing of arteries.
Treatments involve lifestyle changes, cholesterol-lowering medications, and in some cases, gene therapies or specialized medications targeting the LDL receptor.
Customer Reviews (3)
Write a reviewThe LDLR protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.
Its purity and consistency guarantee reliable and reproducible results, ensuring the reliability of my research outcomes.
the LDLR protein offers superior quality and reliability, making it a perfect fit for my experimental needs.
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