Recombinant Human LPL, FLAG-tagged

• Cat.No.: LPL-27722TH
• Product Overview: Recombinant Full length Human Lipoprotein lipase with an N terminal DDDDK tag; 461 amino acids, MWt 51.8kDa.

Specification

• Description: LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism.
• Protein length: 448 amino acids
• Conjugation: FLAG
• Molecular Weight: 51.800kDa inclusive of tags
• Source: HEK 293 cells
• Form: Lyophilised:Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at –80°C for long term sto
• Purity: Densitometry
• Storage buffer: pH: 7.50Constituents:0.24% Tris buffer, 0.29% Sodium chloride
• Storage: Store at -80°C
• Sequences of amino acids: HVDYKDDDDKPAGADQRRDFIDIESKFALRTPEDTAEDTC HLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPK LVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQD VARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNK KVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTR GSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAE RGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSK EAFEKGLCLSCRKNRCNNLGYEISKVRAKRSSKMYLKTRS QMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESE NIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSY FSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQ KGKAPAVFVKCHDKSLNKKSG
• Sequence Similarities: Belongs to the AB hydrolase superfamily. Lipase family.Contains 1 PLAT domain.

Gene Information

• Gene Name: LPL lipoprotein lipase [ Homo sapiens ]
• Official Symbol: LPL
• Synonyms: LPL; lipoprotein lipase; LIPD
• Gene ID: 4023
• mRNA Refseq: NM_000237
• Protein Refseq: NP_000228
• Uniprot ID: P06858
• Chromosome Location: 8p22
• Pathway: Adipogenesis, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Chylomicron-mediated lipid transport, organism-specific biosystem; Developmental Biology, organism-specific biosystem
• Function: heparin binding; hydrolase activity; lipoprotein lipase activity; lipoprotein lipase activity; lipoprotein lipase activity