Recombinant Human WNT3A
Cat.No. : | WNT3A-1700H |
- Specification
- Gene Information
- Related Products
Cat. No. : | WNT3A-1700H |
Description : | Wingless-type MMTV integration site family, member 3A, also known as WNT3A is an intercellular signaling molecule. WNT3A is expressed extensively in cells fated to give rise to embryonic mesoderm. Wnt-3a regulates survival, expansion, and maintenance of neural progenitors derived from embryonic stem cells. It has been reported that Wnt-3a supports self-renewal of embryonic stem cells and can maintain these cells in a pluripotent state. Wnt-3a is also considered a ligand that activates the beta-catenin-dependent pathway in Wnt signaling, which is implicated in numerous physiological events such as morphogenesis. |
Source : | CHO. |
State Of Matter : | Lyophilized. |
Purity : | >75% as determined by SDS-PAGE under reducing conditions. |
Endotoxin : | <0.1 EU/µg as determined by the LAL method. |
Molecular Weight : | The predicted molecular weight of Recombinant Human WNT-3a (Ser19 - Lys352) is Mr 37.4 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 40 kDa. |
Formulation : | The protein was 0.2 µm filtered and lyophilized from PBS, 1.0 mM EDTA, 0.5% CHAPS, pH 6.8. |
Biological Activity : | The biological activity of Human WNT-3a was determined by its ability to promote alkaline phosphatase production by MC3T3E1 cells. The expected ED50 is 5-25 ng/ml. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C for up to three months in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Publication : |
Fibrinogen Induces RUNX2 Activity and Osteogenic Development from Human Pluripotent Stem Cells. (2016)
Lineage-specific differentiation of osteogenic progenitors from pluripotent stem cells reveals the FGF1-RUNX2 association in neural crest-derived osteoprogenitors (2020)
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Gene Name : | WNT3A wingless-type MMTV integration site family, member 3A [ Homo sapiens ] |
Synonyms : | wingless-type MMTV integration site family, member 3A; MGC119418; MGC119419; MGC119420; WNT3A; OTTHUMP00000035713 |
Gene ID : | 89780 |
mRNA Refseq : | NM_033131 |
Protein Refseq : | NP_149122 |
MIM : | 606359 |
UniProt ID : | P56704 |
Chromosome Location : | 1q42 |
Pathway : | Basal cell carcinoma; Hedgehog signaling pathway; Melanogenesis; Pathways in cancer; Wnt signaling pathway |
Function : | extracellular matrix structural constituent; protein binding; signal transducer activity |
Products Types
◆ Recombinant Protein | ||
Wnt3a-1050M | Recombinant Mouse Wnt3a Protein, His-tagged | +Inquiry |
WNT3A-10196M | Recombinant Mouse WNT3A Protein, His (Fc)-Avi-tagged | +Inquiry |
WNT3A-55H | Active Recombinant Human WNT3A Protein, Animal Free | +Inquiry |
Wnt3a-586R | Recombinant Rat Wnt3a Protein, His-tagged | +Inquiry |
Wnt3a-56M | Active Recombinant Mouse Wnt3a Protein | +Inquiry |
◆ Lysates | ||
WNT3A-295HCL | Recombinant Human WNT3A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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