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Cat. No. |
BDNF-334H |
|
Description |
BDNF is a member of
the NGF family of neurotrophic growth factors. Like other members of
this family, BDNF supports neuron proliferation and survival. BDNF
acts on certain neurons of the central nervous system and the
peripheral nervous system, helping to support the survival of
existing neurons and encourage the growth and differentiation of new
neurons and synapses. In the brain, it is active in the hippocampus,
cortex, and basal forebrain-areas vital to learning, memory, and
higher thinking. |
|
Source |
Sf21
Insect Cells. |
|
Molecular Weight |
The predicted
molecular weight of Recombinant Human BDNF is Mr 13.7 and 12.8 kDa
(N-terminal truncated). However, the actual molecular weight as
observed by migration on SDS Page is Mr 13.5 and 12.8 kDa
(N-terminal truncated). |
|
State Of Matter |
Lyophilized. |
|
Purity |
>97% by SDS Page
and analyzed by silver stain. |
|
Endotoxin |
<1.0 EU/µg as
determined by the LAL method. |
|
Biological Activity |
The biological
activity of Human BDNF was determined by its ability to stimulate
proliferation of the TrkB transfected cell line, Baf-TrkB. The
expected ED50 for this effect is typically 3 - 10 ng/mL. |
|
Storage And
Stability |
This lyophilized
protein is stable for six to twelve months when stored desiccated at
-20oC to -70oC. After aseptic reconstitution, this protein may be
stored at 2oC to 8oC for one month or at -20oC to -70oC in a manual
defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
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Gene Information
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Gene Name |
BDNF brain-derived neurotrophic factor [ Homo sapiens ] |
|
Synonyms
|
BDNF; brain-derived
neurotrophic factor; MGC34632; Abrineurin; neurotrophin;
Brain-derived neurotrophic factor |
|
GeneID |
627 |
|
mRNA Refseq |
NM_001143805 |
|
Protein Refseq |
NP_001137277 |
|
MIM |
113505 |
|
UniProt ID |
P23560 |
|
Chromosome Location |
11p13 |
|
Pathway |
Huntington"s
disease; MAPK signaling pathway; Neurotrophin signaling pathway |
|
Function |
Growth factor
activity |
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