Recombinant Human RPS6

• Cat.No.: RPS6-30769TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-249 of Human RPS6, plus N-terminal tag 29kDa.

Specification

• Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
• Source: E. coli
• Form: Lyophilised:Reconstitution with 163 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADA LGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLS KGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKK GEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQY VVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIAL KKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRR RLSSLRASTSKSESSQK
• Sequence Similarities: Belongs to the ribosomal protein S6e family.

Gene Information

• Gene Name: RPS6 ribosomal protein S6 [ Homo sapiens ]
• Official Symbol: RPS6
• Synonyms: RPS6; ribosomal protein S6; 40S ribosomal protein S6; phosphoprotein NP33; S6
• Gene ID: 6194
• mRNA Refseq: NM_001010
• Protein Refseq: NP_001001
• MIM: 180460
• Uniprot ID: P62753
• Chromosome Location: 9p21
• Pathway: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Cytoplasmic Ribosomal Proteins, organism-specific biosystem; Developmental Biology, organism-specific biosystem
• Function: protein binding; structural constituent of ribosome