Recombinant Human STAT1
Cat.No. : | STAT1-30902TH |
Product Overview : | Recombinant full length protein STAT1 beta (Human) with N terminal tag |
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Description : | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. |
Source : | E. coli |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the transcription factor STAT family.Contains 1 SH2 domain. |
Gene Name : | STAT1 signal transducer and activator of transcription 1, 91kDa [ Homo sapiens ] |
Official Symbol : | STAT1 |
Synonyms : | STAT1; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1-alpha/beta; ISGF 3; STAT91; transcription factor ISGF 3 components p91/p84; |
Gene ID : | 6772 |
mRNA Refseq : | NM_007315 |
Protein Refseq : | NP_009330 |
MIM : | 600555 |
Uniprot ID : | P42224 |
Chromosome Location : | 2q32.2-q32.3 |
Pathway : | Adipogenesis, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; |
Function : | DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; calcium ion binding; non-membrane spanning protein tyrosine kinase activity; |
Products Types
◆ Recombinant Protein | ||
STAT1-2741H | Recombinant Human STAT1 Protein, His-tagged | +Inquiry |
STAT1-2115H | Recombinant Human STAT1 Protein, His (Fc)-Avi-tagged | +Inquiry |
STAT1-7037H | Recombinant Human STAT1 protein(Met1-Val712), His&GST-tagged | +Inquiry |
STAT1-2901H | Recombinant Human STAT1 Protein, MYC/DDK-tagged | +Inquiry |
STAT1-01H | Recombinant Human STAT1 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
STAT1-555HCL | Recombinant Human STAT1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionSTAT1 is a signal transduction and transcriptional activator involved in regulating a variety of biological processes such as cell growth, differentiation, apoptosis, and immune response.
Mutations in the STAT1 gene have been found to be associated with a variety of diseases, including autoimmune diseases, primary immunodeficiency diseases, and malignant tumors.
The STAT1 protein is primarily activated by the JAK-STAT signaling pathway. When activated by the receptor, JAK kinase phosphorylates the STAT1 protein, allowing it to form dimers and enter the nucleus to regulate transcription of related genes.
The STAT1 protein plays an important role in many diseases, including tumors, immune-related diseases (such as immunodeficiency diseases, autoimmune diseases), infectious diseases (such as viral infections), etc.
Some activators or inhibitors of the STAT1 protein have been identified. These compounds can be used to study the function of the STAT1 protein and the development of disease treatments.
The STAT1 protein plays an important role in viral infection. It mediates interferon signaling, promotes antiviral immune responses, and inhibits viral replication and transmission.
Customer Reviews (3)
Write a reviewIt is well suited for our laboratory to induce specific immune responses.
It has great application potential and performs well in all aspects.
This protein has high yield and high purity, which greatly improves our production efficiency.
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