Recombinant Human TDGF1, MBP-tagged

• Cat.No.: TDGF1-27822TH
• Product Overview: Recombinant full length Human Cripto1 with MBP tag; 596 amino acids with tag, MWt 65.8kDa.

Specification

• Description: This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants.
• Conjugation: MBP
• Source: E. coli
• Tissue specificity: Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts.
• Form: Lyophilised
• Storage buffer: Preservative: NoneConstituents: PBS, pH 7.4
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 1 EGF-like domain.

Gene Information

• Gene Name: TDGF1 teratocarcinoma-derived growth factor 1 [ Homo sapiens ]
• Official Symbol: TDGF1
• Synonyms: TDGF1; teratocarcinoma-derived growth factor 1; CR; CRIPTO; Cripto 1
• Gene ID: 6997
• mRNA Refseq: NM_001174136
• Protein Refseq: NP_001167607
• Uniprot ID: P13385
• Chromosome Location: 3p21.31
• Pathway: Developmental Biology, organism-specific biosystem; Glypican 1 network, organism-specific biosystem; Regulation of Signaling by NODAL, organism-specific biosystem; Signaling by NODAL, organism-specific biosystem
• Function: growth factor activity; protein binding; receptor binding