Recombinant Human THBD protein

Cat.No.: THBD-31177TH
Product Overview: Recombinant Human THBD was expressed in HEK293.
Description: Thrombomodulin (TM, CD141, THBD) is an endothelial cell expressed transmembrane glycoprotein that can form a complex with the coagulation factor, Thrombin. The Thrombomodulin/Thrombin complex converts protein C to its activated form, protein Ca, which in turn proteolytically cleaves and deactivates factor Va and factor VIIIa, two essential components of the coagulation mechanism. This inactivation reduces the generation of additional thrombin and thereby effectively prevents continued coagulation. Reduced levels of Thrombomodulin can correlate with the pathogenesis of certain cardiovascular diseases, such as atherosclerosis and thrombosis. However, the serum levels of the truncated circulating form of Thrombomodulin are typically elevated during inflammation and in the presence of various inflammatory related diseases.
Source: HEK293
Species: Human
Form: Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 7.5.
Bio-activity: Measured by its ability to activate protein C induced cleavage of the chromogenic substrate, BOC-Asp-Pro Arg-AMC in the presence of thrombin. The specific activity is greater than 500 pmoles/min/ug.
Protein length: 491 aa
AA Sequence: APAEPQPGG SQCVEHDCF ALYPGPATF LNASQICDG LRGHLMTVR SSVAADVIS LLLNGDGGV GRRRLWIGL QLPPGCGDP KRLGPLRGF QWVTGDNNT SYSRWARLD LNGAPLCGP LCVAVSAAE ATVPSEPIW EEQQCEVKA DGFLCEFHF PATCRPLAV EPGAAAAAV SITYGTPFA ARGADFQAL PVGSSAAVA PLGLQLMCT APPGAVQGH WAREAPGAW DCSVENGGC EHACNAIPG APRCQCPAG AALQADGRS CTASATQSC NDLCEHFCV PNPDQPGSY SCMCETGYR LAADQHRCE DVDDCILEP SPCPQRCVN TQGGFECHC YPNYDLVDG ECVEPVDPC FRANCEYQC QPLNQTSYL CVCAEGFAP IPHEPHRCQ MFCNQTACP ADCDPNTQA SCECPEGYI LDDGFICTD IDECENGGF CSGVCHNLP GTFECICGP DSALARHIG TDCDSGKVD GGDSGSGEP PPSPTPGST LTPPA
Endotoxin: Endotoxin level is < 0.1ng/ug of protein(<1 EU/ug)
Purity: Above 98% as determined by SDS-PAGE Analysis.
Storage: Stored at -20 centigrade
Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended containing a carrier protein(example 0.1% BSA)and store in working aliquots at -20 centigrade to -80 centigrade.
Gene Name: THBD thrombomodulin [ Homo sapiens ]
Official Symbol: THBD
Synonyms: THBD; thrombomodulin; CD141; fetomodulin; CD141 antigen; TM; THRM; AHUS6; BDCA3; THPH12;
Gene ID: 7056
mRNA Refseq: NM_000361
Protein Refseq: NP_000352
MIM: 188040
UniProt ID: P07204
Chromosome Location: 20p12-cen
Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function: calcium ion binding; protein binding; receptor activity; transmembrane signaling receptor activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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