Recombinant Human WWP1, GST-tagged

• Cat.No.: WWP1-477H
• Product Overview: Recombinant Human WWP1, amino acids 2-end with N-terminal FLAG tag expressed inSf9expression system. MW = 106kDa.

Specification

• Cat. No.: WWP1-477H
• Description: NEDD4-like E3 ubiquitin-protein ligase WWP1 is an enzyme that in humans is encoded by the WWP1 gene. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain.
• Source: Sf9.
• Purity: >15%.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT.
• Stability: >6 months at –80°C.

Gene Information

• Gene Name: WWP1 WW domain containing E3 ubiquitin protein ligase 1 [ Homo sapiens ]
• Synonyms: WWP1; WW domain containing E3 ubiquitin protein ligase 1; AIP5; Tiul1; hSDRP1; DKFZp434D2111; WW domain containing E3 ubiquitin protein ligase 1; atrophin-1 interacting protein 5; TGIF-interacting ubiquitin ligase 1; Nedd-4-like ubiquitin-protein ligase
• Gene ID: 11059
• mRNA Refseq: NM_007013
• Protein Refseq: NP_008944
• MIM: 602307
• UniProt ID: Q9H0M0
• Chromosome Location: 8q21
• Pathway: Endocytosis; Ubiquitin mediated proteolysis
• Function: acid-amino acid ligase activity; ligase activity; ubiquitin-protein ligase activity; protein binding