Recombinant Human BMX Non-receptor Tyrosine Kinase, Active

• Cat.No.: BMX-654H

Specification

• Cat. No.: BMX-654H
• Description: The BMX gene encodes a non-receptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells. The BMX gene is located on chromosomal band Xp22.2 between the DXS197 and DXS207 loci. Interestingly, chromosome X also contains the closest relative of BMX, the BTK gene, implicated in X-linked agammaglobulinemia. BMX, is found to induce activation of the Stat signaling pathway.
• Source: Escherichia coli.
• Biochem/physiol Actions: The BMX gene encodes a novel non-receptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells. Bmx induces the activation of the Stat-signaling pathway.
• Unit Definition: Kinase activity is measured as the molar amount of phosphate incorporated into Poly Glu-Tyr substrate per minute per mg protein at 30 °C using a final concentration of 50 μM [32P]-ATP.
• Physical Form: Solution of 50 μL in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, and 30% glycerol.
• Assay: ≥85% (SDS-PAGE).
• Form: buffered aqueous glycerol solution.
• Mol Wt: apparent mol wt ~110 kDa.
• Storage Temp: −70°C.
• Pathways: Apoptosis

Gene Information

• Gene Name: BMX BMX non-receptor tyrosine kinase [ Homo sapiens ]
• Synonyms: BMX non-receptor tyrosine kinase; ETK; PSCTK2; PSCTK3; BMX; OTTHUMP00000022965; NTK38 tyrosine kinase; Etk/Bmx cytosolic tyrosine kinase; cytoplasmic tyrosine-protein kinase BMX; EC 2.7.10.2; NTK38; OTTHUMP00000022964; OTTHUMP00000022966; Epithelial and endothelial tyrosine kinase; Bone marrow tyrosine kinase gene in chromosome X protein
• Gene ID: 660
• mRNA Refseq: NM_001721
• Protein Refseq: NP_001712
• MIM: 300101
• UniProt ID: P51813
• Chromosome Location: Xp22.2
• Function: non-membrane spanning protein tyrosine kinase activity; ATP binding; metal ion binding; nucleotide binding; protein binding; signal transducer activity; transferase activity; zinc ion binding

Reviews

02/22/2022

Accurate mass spectrometry analysis; essential for proteomics research.

10/02/2021

Reliable western blot results; a staple for our lab work.

10/15/2018

Precise protein quantification; vital for our research projects.

Q&As

How does BMX interact with other members of the Tec family kinases in immune cell signaling?

BMX interacts with Tec family kinases to regulate immune cell signaling, affecting immune responses.

What are the effects of BMX inhibition on the angiogenesis process in tumor models?

Inhibition of BMX reduces angiogenesis in tumor models, suggesting a role in tumor growth and metastasis.

What are the potential therapeutic applications of targeting BMX in cardiovascular diseases?

Targeting BMX in cardiovascular diseases offers potential therapeutic benefits, possibly impacting vascular remodeling and function.

What are the specific substrates of BMX kinase in different cell types and how do they influence cell signaling pathways?

BMX kinase substrates vary by cell type, impacting diverse signaling pathways related to cell growth and survival.

How does the expression of BMX vary in normal versus cancerous tissues, particularly in breast and prostate cancers?

BMX expression differs in cancerous tissues, with heightened levels in certain breast and prostate cancers, indicating a potential role in tumor progression.

What role does BMX play in the regulation of inflammatory responses in autoimmune diseases?

BMX is involved in regulating inflammatory responses, playing a significant role in autoimmune disease mechanisms.

How does phosphorylation affect the activity and stability of BMX in cellular contexts?

Phosphorylation alters BMX activity and stability, influencing its function in cellular signaling processes.