Recombinant Human Coagulation Factor VIII, Procoagulant Component

• Cat.No.: F8-2397H
• Product Overview: Recombinant Human Coagulation Factor VIII, Procoagulant Component(2597-2791aa) is expressed inE.coli. MW=48kDa.

Specification

• Cat. No.: F8-2397H
• Description: Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Von Willebrand factor is synthesized by endothelial cells and stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. Von Willebrand factor is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms.
• Source: E. coli.
• Presentation: 100μl purified human factor VIII protein at 100μg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol without BSA and Sodium Azide.
• Application: ELISA, Inhibition Assays, Western Blotting.
• Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 48kDa including GST.
• Storage: Store vial at -20℃ to -80℃. When stored at the recommended temperature, this protein is stable for 12 months.

Gene Information

• Gene Name: F8 coagulation factor VIII, procoagulant component [ Homo sapiens ]
• Synonyms: F8; coagulation factor VIII, procoagulant component; AHF; F8B; F8C; HEMA; FVIII; DXS1253E; coagulation factor VIII; factor VIII F8B; coagulation factor VIIIc; antihemophilic factor
• Gene ID: 2157
• mRNA Refseq: NM_000132
• Protein Refseq: NP_000123
• MIM: 306700
• UniProt ID: P00451
• Chromosome Location: Xq28
• Pathway: Complement and coagulation cascades; Hemostasis
• Function: copper ion binding; metal ion binding; oxidoreductase activity; protein binding