Active Recombinant Human DUSP6 Protein

• Cat.No.: DUSP6-631H
• Product Overview: Recombinant full length MKP-3 without tag was produced in Sf9 insect cells.

Specification

• Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.
• Source: Insects cell
• Species: Human
• Form: Liquid
• Bio-activity: ≥10 U/mg assayed by 3-O-methyl fluorescein phosphate (OMFP) hydrolysis at pH 8.2, 30 centigrade. One unit is equal to 1 nmole phosphate hydrolyzed from OMFP per minute.
• Molecular Mass: 42 kDa
• Storage: Store at -80 centigrade.
• Storage Buffer: In 20mM TRIS/HCl, pH 8.0, 200mM NaCl, 5mM DTT, 0.1 % Tween-20, 10% glycerol.
• Shipping: Dry ice
• Publication:
  Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. (2014)

Gene Information

• Gene Name: DUSP6 dual specificity phosphatase 6 [ Homo sapiens (human) ]
• Official Symbol: DUSP6
• Synonyms: DUSP6; dual specificity phosphatase 6; HH19; MKP3; PYST1; dual specificity protein phosphatase 6; MAP kinase phosphatase 3; dual specificity protein phosphatase PYST1; mitogen-activated protein kinase phosphatase 3; serine/threonine specific protein phosphatase; EC 3.1.3.16; EC 3.1.3.48
• Gene ID: 1848
• mRNA Refseq: NM_001946
• Protein Refseq: NP_001937
• MIM: 602748
• UniProt ID: Q16828