Recombinant Human Hemochromatosis Type 2 (Juvenile), FLAG-tagged
Cat.No. : | HFE2-2419H |
Product Overview : | Recombinant Human RGMC (aa 36-398) produced in HEK 293 cells is fused at the N-terminus to a linker peptide (8 aa) and a FLAG-tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | HFE2-2419H |
Description : | The RGMC (also called Hemojuvelin) is an GPI-anchored protein involved in the iron metabolism through regulation of hepcidin expression. Mutations in the gene encoding RGMC cause severe iron overload (juvenile hemochromatosis /hemochromatosis type 2A). The protein binds to neogenin and acts as co-receptor of the bone morphogenetic protein. The mature RGMc protein is proteolytically processed and glycosylated. |
Source/Host : | HEK 293 cells. |
Concentration : | 0.1mg/ml after reconstitution. |
Purity : | ≥95% (SDS-PAGE). |
Endotoxin Content : | <0.1EU/µg purified protein (LAL test; Bio Whittaker). |
Reconstitution : | Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum. |
Short Term Storage : | -20°C. |
Formulation : | Lyophilized. Contains PBS. |
Long Term Storage : | -20°C. |
Use/Stability : | Stable for at least 6 months after receipt when stored at -20°C. |
Handling : | After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
Gene Name : | HFE2 hemochromatosis type 2 (juvenile) [ Homo sapiens ] |
Synonyms : | hemochromatosis type 2 (juvenile); JH; HJV; RGMC; HFE2A; MGC23953; HFE2; hemojuvelin; haemojuvelin; RGM domain family member C; hemochromatosis type 2 protein; Hemochromatosis type 2 protein; RGM domain family, member C; LEAP1; HAMP; HEPC |
Gene ID : | 148738 |
mRNA Refseq : | NM_145277 |
Protein Refseq : | NP_660320 |
MIM : | 608374 |
UniProt ID : | Q6ZVN8 |
Chromosome Location : | 1q21.1 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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