Recombinant Human COCH protein(Glu25-Gln550), His-tagged
Cat.No. : | COCH-3207H |
Product Overview : | Recombinant Human COCH (NP_001128530.1) (Glu 25-Gln 550) was expressed in HEK293, with a polyhistidine tag at the N-terminus. |
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Source : | HEK293 |
Species : | Human |
Tag : | N-His |
Protein length : | Glu25-Gln550 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Molecular Mass : | The recombinant human COCH consists of 542 amino acids and has a calculated molecular mass of 59.4 kDa. In SDS-PAGE under reducing conditions, rhCOCH migrates as three bands with apparent molecular mass of 66, 48 and 18 kDa, corresponding to the alternative splicing isoforms. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 92 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | COCH coagulation factor C homolog, cochlin (Limulus polyphemus) [ Homo sapiens ] |
Official Symbol : | COCH |
Synonyms : | COCH; coagulation factor C homolog, cochlin (Limulus polyphemus); coagulation factor C (Limulus polyphemus homolog); cochlin , DFNA9, DFNA31; cochlin; COCH 5B2; DFNA9; COCH5B2; COCH-5B2; |
Gene ID : | 1690 |
mRNA Refseq : | NM_001135058 |
Protein Refseq : | NP_001128530 |
MIM : | 603196 |
UniProt ID : | O43405 |
Products Types
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◆ Lysates | ||
COCH-2373HCL | Recombinant Human COCH cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMutations in COCH can lead to impaired cochlear function, resulting in hearing and balance disorders.
It plays a key role in the structural integrity and mechanical properties of the cochlear extracellular matrix.
COCH works with other cochlear proteins to maintain the mechanics and signal transduction necessary for hearing.
Therapeutic strategies targeting COCH could offer new treatments for genetic and age-related hearing loss.
COCH dysfunction is associated with the progression of age-related hearing loss, affecting cochlear homeostasis.
COCH is essential for maintaining the structure and function of the cochlea, crucial for hearing.
COCH dysfunctions are closely linked to various types of hearing loss, including sensorineural hearing loss.
Customer Reviews (3)
Write a reviewKey contributor to our research discoveries.
Swift and accurate service, a research necessity.
Invaluable support for our protein experiments.
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