Recombinant Human TIMP Metallopeptidase Inhibitor 2

• Cat.No.: TIMP2-2529H

Specification

• Cat. No.: TIMP2-2529H
• Description: TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells.
• Source: CHO.
• Analysis Note: The biological activity is measured by the ability to inhibit human MMP-2 hydrolysis of a fluorogenic MMP substrate.
• Biochem/physiol Actions: TIMP-2 has a greater binding efficiency to MMP-2 than the other MMPs. Although TIMP-2 is an inhibitor of MMP-2, it is also required at low concentrations for the activation of MMP-2.
• Physical Form: Lyophilized from a 0.2 μm filtered solution in 25 mM Tris, 50 mM sodium chloride, and 0.05% sodium azide, pH 7.5.
• Assay: >95% (SDS-PAGE).
• Form: lyophilized powder.
• Mol Wt: apparent mol wt ~20 kDa.
• Storage Temp: −20°C.

Gene Information

• Gene Name: TIMP2 TIMP metallopeptidase inhibitor 2 [ Homo sapiens ]
• Synonyms: TIMP2; TIMP metallopeptidase inhibitor 2; CSC-21K; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2; TIMP-2
• Gene ID: 7077
• mRNA Refseq: NM_003255
• Protein Refseq: NP_003246
• MIM: 188825
• UniProt ID: P16035
• Chromosome Location: 17q25
• Function: enzyme activator activity; enzyme inhibitor activity; integrin binding; metalloendopeptidase inhibitor activity; protein binding