Haemocoagulase
| Cat.No. : | CED39 |
| Product Overview : | Batroxobin is a thrombin-like proteolytic enzyme isolated from the venom of Bothrops atrox. It splits the 16 Arg-17 Gly bond in the Aα-chain of fibrinogen and causes the release of fibrinopeptide A and the formation of fibrin I monomer or Des-AA-monomer which spontaneously aggregates into a clot of fibrin I. Batroxobin also induces the release of tPA from endothelium. |
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| Cat. No. : | CED39 |
| Description : | Batroxobin is a serine protease derived from the venom of Bothrops atrox. Its molecular weight is approximately 43,000 g/mol−1. This thrombin-like proteolytic enzyme splits the 16 Arg-17 Gly bond in the A(alpha)-chain of fibrinogen, releasing fibrinopeptide A and leading to the clot formation through aggregation of formed of fibrin I monomer or Des-AA-monomer. In contrast to other anti-coagulants, it does not affect the functions of platelets. Hence, Batroxobin is used to determine fibrinogen in plasma, to measure a ''batroxobin clotting time'' as a heparin-insensitive parallel to the thrombin time, to investigate dysfibrinogenemia, and to test the contractile system of platelets. |
| Application : | Due to its specific action on fibrinogen and its ability to clot platelet-rich plasma without affecting the integrity and functions of the platelets, and thanks to its insensitivity to thrombin inhibitors, batroxobin has found several applications as a tool in blood coagulation research and diagnosis. Batroxobin can be used to determine fibrinogen in plasma, to measure the batroxobin clotting time (Reptilase time) as a heparin-insensitive parallel to the thrombin time, to investigate dysfibrinogenemia, and to test the contractile system of platelets. |
| Origin : | Bothrops atrox snake venom |
| MW : | approx. 43'000 |
| Storage : | May be used by the expiry date given on the label when stored unopened, protected from moisture. Avoid contamination of the reagents by micro-organisms. Shipment of product does not require cooling during the time of transportation. Store at -20°C. |
| Synonyms : | Thrombin-like enzyme batroxobin; EC 3.4.21.74; BX; Bothrops atrox serine proteinase; Venombin-A; Defibrase; Reptilase; Batroxobin. |
| Synonyms : | Thrombin-like enzyme batroxobin; EC 3.4.21.74; BX; Bothrops atrox serine proteinase; Venombin-A; Defibrase; Reptilase; Batroxobin. |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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