Human TDG protein

• Cat.No.: TDG-7443H

Specification

• Description: TDG is a DNA glycosylase that removes T from the TG mismatch in DNA. Such mismatch can derive from deamination of methylated C in DNA. TDG is a mono functional glycosylase that leaves an intact AP site in DNA following its glycosylase action. In addition to T, U or ethenoC opposite G is also recognized by TDG.
• Species: Human
• Form: The protein is supplied in 20 mM sodium phosphate (pH 7.5), 150 mM NaCl, 5 mM β- mercaptoethanol, 10% glycerol.

Gene Information

• Gene Name: TDG thymine-DNA glycosylase [ Homo sapiens ]
• Official Symbol: TDG
• Synonyms: TDG; thymine-DNA glycosylase; G/T mismatch-specific thymine DNA glycosylase; EC 3.2.2.29
• Gene ID: 6996
• mRNA Refseq: NM_003211
• Protein Refseq: NP_003202
• MIM: 601423
• UniProt ID: Q13569
• Chromosome Location: 12q24.1
• Pathway: Base excision repair, conserved biosystem; Depyrimidination, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base-Excision Repair, AP Site Formation, organism-specific biosyst
• Function: damaged DNA binding; mismatched DNA binding; protein binding; pyrimidine-specific mismatch base pair DNA N-glycosylase activity