Insulin-like growth Factor Binding Protein-3 Reference standard

• Cat.No.: IGFBP3-197H
• Product Overview: This consists of a batch of ampoules containing non- glycosylated recombinant DNA-derived insulin-like growth factor binding protein-3 (rhIGFBP-3) expressed in E. coli.

Specification

• Source: E.coli
• Species: Human
• Enzyme Unit: This material is issued on the understanding that it has no official status and has no definitive unitage or content ascribed to it.
• Usage: For practical purposes each ampoule contains the same quantity of IGFBP- 3. The entire contents of each ampoule should be completely dissolved in an accurately measured amount of buffer solution. No attempt should be made to weigh out portions of the freeze dried powder. The use of water to reconstitute ampoule contents is not recommended. The material has not been sterilized and the ampoules contain no bacteriostat.
• Notes: This preparation is not for administration to humans. The material is of bovine origin. The material is certified to be obtained from animals taken from a closed herd in the female line since 1980, in which no animal has been clinically suspected of having BSE & which has not been fed rations containing ruminant derived protein during that period. As with all materials of biological origin, this preparation should be regarded as potentially hazardous to health. It should be used and discarded according to your own laboratorys safety procedures. Such safety procedures should include the wearing of protective gloves and avoiding the generation of aerosols. Care should be exercised in opening ampoules or vials, to avoid cuts.
• Stability: They remain valid with the assigned potency and status until withdrawn or amended. Reference materials are held at Creative Biomart within assured, temperature- controlled storage facilities. Reference Materials should be stored on receipt as indicated on the label. In addition, once reconstituted, diluted or aliquoted, users should determine the stability of the material according to their own method of preparation, storage and use. Users who have data supporting any deterioration in the characteristics of any reference preparation are encouraged to contact Creative Biomart.
• Storage: Unopened ampoules should be stored at –20°C. Please note: because of the inherent stability of lyophilized material, Creative Biomart may ship these materials at ambient temperature.

Gene Information

• Gene Name: IGFBP3 insulin-like growth factor binding protein 3 [ Homo sapiens ];
• Official Symbol: IGFBP3
• Synonyms: IBP3; BP-53; insulin-like growth factor-binding protein 3; IBP-3; IGFBP-3; binding protein 29; binding protein 53; IGF-binding protein 3; growth hormone-dependent binding protein; acid stable subunit of the 140 K IGF complex
• Gene ID: 3486
• mRNA Refseq: NM_000598
• Protein Refseq: NP_000589
• MIM: 146732
• UniProt ID: P17936
• Chromosome Location: 7p12.3
• Pathway: Direct p53 effectors, organism-specific biosystem; Integrated Pancreatic Cancer Pathway, organism-specific biosystem; Senescence and Autophagy, organism-specific biosystem
• Function: fibronectin binding; insulin-like growth factor I binding; protein binding

Reviews

05/04/2020

A manufacturer that offers customization options can enable the researcher to adhere to their experimental design requirements more effectively.

01/20/2019

A reliable manufacturer should be able to provide a consistently pure and high-quality IGFBP3 protein, ensuring that the samples are suitable for research purposes.

01/02/2019

This can help ensure compatibility between different components used in the trials and ease the overall experimental workflow.

Q&As

Are there any genetic factors that influence IGFBP3 protein levels?

Yes, genetic variations can affect IGFBP3 expression, potentially leading to differences in protein levels among individuals.

How does IGFBP3 protein influence bone health?

IGFBP3 is involved in bone metabolism and is associated with bone mineral density. Low levels of IGFBP3 have been linked to decreased bone density and increased risk of fractures.

Are there any side effects associated with therapies targeting IGFBP3?

The potential side effects of therapies targeting IGFBP3 are still being studied, and it varies depending on the specific treatment approach being used.

How do lifestyle factors such as diet and exercise influence IGFBP3 levels?

Healthy lifestyle choices, including a balanced diet and regular exercise, can positively influence IGFBP3 levels, promoting overall health and reducing the risk of related diseases.

What are the implications of IGFBP3 deficiency in children's growth and development?

IGFBP3 deficiency can impact children's growth and development, potentially leading to short stature and delayed puberty, as IGFBP3 is a key regulator of growth hormone actions.