Native Human Glutamic-Oxaloacetic Transaminase 1, Soluble (aspartate aminotransferase 1)

• Cat.No.: GOT1-5351H
• Product Overview: Native Human GOT1 isderived from Human Heart.

Specification

• Cat. No.: GOT1-5351H
• Description: TwoGOT isoenzymes are present in humans. They have high similarity. GOT1, thecytosolic isoenzyme, derives mainly from red blood cells and heart. GOT2, themitochondrial isoenzyme is predominantly present in liver.
• Form: Lyophilized
• Source: Human Heart
• Molecular Weight: 92 kDa
• Endotoxin Level: < 0.1 ng/ug of protein
• Biological Activity: One unit willcatalyze the transamination of one micromole of L-aspartate toα-ketoglutarate forming L-glutamate and oxaloacetate per minute at 37°C andpH 7.8. Measured at 340 nm as one equimolar amount of NAD produced by a coupledreaction.
• Storage: Store at -80oC. Stablefor 3 years from delivery. Avoid repeated freeze-thaw cycles.
• Pathways: Alanine, aspartate andglutamate metabolism; Arginine and proline metabolism; Cysteine andmethionine metabolism; Metabolic pathways; Phenylalanine metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis; Tyrosine metabolism

Gene Information

• Gene Name: GOT1 glutamic-oxaloacetictransaminase 1, soluble (aspartate aminotransferase 1) [ Homo sapiens]
• Official Symbol: GOT1
• Synonyms: GOT1; glutamic-oxaloacetictransaminase 1, soluble (aspartate aminotransferase 1); GIG18; aspartateaminotransferase, cytoplasmic; transaminase A; growth-inhibiting protein 18;glutamate oxaloacetate transaminase 1; EC 2.6.1.1
• Gene ID: 2805
• mRNA Refseq: NM_002079
• Protein Refseq: NP_002070
• MIM: 138180
• UniProt ID: P17174
• Chromosome Location: 10q24.1-q25.1
• Function: L-aspartate:2-oxoglutarateaminotransferase activity; carboxylic acid binding; phosphatidylserinedecarboxylase activity; pyridoxal phosphate binding